Assessment of liver function in chickens using galactose and indocyanine green clearances

S. M. Jaensch, L. Cullen, S. R. Raidal

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Values for galactose and indocyanine green (ICG) clearances, and plasma and serum biochemical markers of liver dysfunction were determined in normal chickens and following coeliotomy, and compared with birds after partial hepatectomy. Clearance tests, and serum and plasma biochemistry were performed 4h, and 4 and 7 days after surgery. Coeliotomy and manipulation of the liver did not delay clearance of either compound. Partial hepatectomy resulted in elevation of galactose single point concentrations but did not significantly alter galactose clearance (GEC) values. Clearance values of ICG were not significantly altered. Biochemical values were not significantly elevated in birds after a partial hepatectomy in comparison with birds after coeliotomy. Galactose single point concentrations have the potential to become a simple, relatively non-invasive method of screening for liver disease, with GEC tests having the potential to quantify the degree of loss of functional hepatic mass.

Original languageEnglish
Pages (from-to)109-116
Number of pages8
JournalAvian Pathology
Volume29
Issue number2
DOIs
Publication statusPublished - Apr 2000

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