Assessment of liver function in galahs (Eolophus roseicapillus) after partial hepatectomy: A comparison of plasma enzyme concentrations, serum bile acid levels, and galactose clearance tests

Susan M. Jaensch, Len Cullen, Shane R. Raidal

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Abstract

The relative sensitivity of conventional assays of liver function was evaluated in comparison with galactose clearance, a test of liver function used in humans since the 1960s. Results of galactose clearance tests were compared with plasma enzyme concentrations and serum bile acid levels in clinically normal galahs (Eolophus roseicapillus; n = 8), after celiotomy (n = 4), and after 6% or 18% hepatectomy (n = 8, respectively). Clearance tests and biochemical analyses were performed within 2-4 hours of surgery and at 4 and 7 days after surgery. Celiotomy and 6% and 18% hepatectomy resulted in changes in alkaline phosphatase, aspartate aminotransferase, and alanine aminotransferase concentrations that were consistent with muscle trauma. Celiotomy and 6% hepatectomy did not significantly alter the results of galactose clearance tests; however, 18% hepatectomy resulted in significant reduction in galactose clearance and galactose clearance as a function of body surface area (GEC-SA). Galactose single-point concentrations were not significantly elevated at any time during the experiments; however, single-point concentrations were strongly correlated with galactose clearance and GEC-SA values, especially at 80 minutes after galactose injection. Serum bile acid levels were not significantly elevated after celiotomy or partial hepatectomy. Measurement of galactose single-point concentrations has the potential to be a simple, sensitive method of screening for reduced hepatic function in birds. Galactose clearance and GEC-SA have the potential to be sensitive assays of hepatic functional mass, for use as a noninvasive method of monitoring hepatic function.

Original languageEnglish
Pages (from-to)164-171
Number of pages8
JournalJournal of Avian Medicine and Surgery
Volume14
Issue number3
Publication statusPublished - 01 Dec 2000

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liver function
Hepatectomy
bile acids
Bile Acids and Salts
Galactose
galactose
Liver
Enzymes
enzymes
Serum
testing
surgery
Body Surface Area
Liver Function Tests
assays
Aspartate Aminotransferases
Alanine Transaminase
Ambulatory Surgical Procedures
alanine transaminase
aspartate transaminase

Cite this

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title = "Assessment of liver function in galahs (Eolophus roseicapillus) after partial hepatectomy: A comparison of plasma enzyme concentrations, serum bile acid levels, and galactose clearance tests",
abstract = "The relative sensitivity of conventional assays of liver function was evaluated in comparison with galactose clearance, a test of liver function used in humans since the 1960s. Results of galactose clearance tests were compared with plasma enzyme concentrations and serum bile acid levels in clinically normal galahs (Eolophus roseicapillus; n = 8), after celiotomy (n = 4), and after 6{\%} or 18{\%} hepatectomy (n = 8, respectively). Clearance tests and biochemical analyses were performed within 2-4 hours of surgery and at 4 and 7 days after surgery. Celiotomy and 6{\%} and 18{\%} hepatectomy resulted in changes in alkaline phosphatase, aspartate aminotransferase, and alanine aminotransferase concentrations that were consistent with muscle trauma. Celiotomy and 6{\%} hepatectomy did not significantly alter the results of galactose clearance tests; however, 18{\%} hepatectomy resulted in significant reduction in galactose clearance and galactose clearance as a function of body surface area (GEC-SA). Galactose single-point concentrations were not significantly elevated at any time during the experiments; however, single-point concentrations were strongly correlated with galactose clearance and GEC-SA values, especially at 80 minutes after galactose injection. Serum bile acid levels were not significantly elevated after celiotomy or partial hepatectomy. Measurement of galactose single-point concentrations has the potential to be a simple, sensitive method of screening for reduced hepatic function in birds. Galactose clearance and GEC-SA have the potential to be sensitive assays of hepatic functional mass, for use as a noninvasive method of monitoring hepatic function.",
keywords = "Bile acids, Biopsy, Birds, Eolophus roseicapillus, Galactose clearance, Galahs, Hepatectomy, Hepatic, Liver function tests",
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T1 - Assessment of liver function in galahs (Eolophus roseicapillus) after partial hepatectomy

T2 - A comparison of plasma enzyme concentrations, serum bile acid levels, and galactose clearance tests

AU - Jaensch, Susan M.

AU - Cullen, Len

AU - Raidal, Shane R.

PY - 2000/12/1

Y1 - 2000/12/1

N2 - The relative sensitivity of conventional assays of liver function was evaluated in comparison with galactose clearance, a test of liver function used in humans since the 1960s. Results of galactose clearance tests were compared with plasma enzyme concentrations and serum bile acid levels in clinically normal galahs (Eolophus roseicapillus; n = 8), after celiotomy (n = 4), and after 6% or 18% hepatectomy (n = 8, respectively). Clearance tests and biochemical analyses were performed within 2-4 hours of surgery and at 4 and 7 days after surgery. Celiotomy and 6% and 18% hepatectomy resulted in changes in alkaline phosphatase, aspartate aminotransferase, and alanine aminotransferase concentrations that were consistent with muscle trauma. Celiotomy and 6% hepatectomy did not significantly alter the results of galactose clearance tests; however, 18% hepatectomy resulted in significant reduction in galactose clearance and galactose clearance as a function of body surface area (GEC-SA). Galactose single-point concentrations were not significantly elevated at any time during the experiments; however, single-point concentrations were strongly correlated with galactose clearance and GEC-SA values, especially at 80 minutes after galactose injection. Serum bile acid levels were not significantly elevated after celiotomy or partial hepatectomy. Measurement of galactose single-point concentrations has the potential to be a simple, sensitive method of screening for reduced hepatic function in birds. Galactose clearance and GEC-SA have the potential to be sensitive assays of hepatic functional mass, for use as a noninvasive method of monitoring hepatic function.

AB - The relative sensitivity of conventional assays of liver function was evaluated in comparison with galactose clearance, a test of liver function used in humans since the 1960s. Results of galactose clearance tests were compared with plasma enzyme concentrations and serum bile acid levels in clinically normal galahs (Eolophus roseicapillus; n = 8), after celiotomy (n = 4), and after 6% or 18% hepatectomy (n = 8, respectively). Clearance tests and biochemical analyses were performed within 2-4 hours of surgery and at 4 and 7 days after surgery. Celiotomy and 6% and 18% hepatectomy resulted in changes in alkaline phosphatase, aspartate aminotransferase, and alanine aminotransferase concentrations that were consistent with muscle trauma. Celiotomy and 6% hepatectomy did not significantly alter the results of galactose clearance tests; however, 18% hepatectomy resulted in significant reduction in galactose clearance and galactose clearance as a function of body surface area (GEC-SA). Galactose single-point concentrations were not significantly elevated at any time during the experiments; however, single-point concentrations were strongly correlated with galactose clearance and GEC-SA values, especially at 80 minutes after galactose injection. Serum bile acid levels were not significantly elevated after celiotomy or partial hepatectomy. Measurement of galactose single-point concentrations has the potential to be a simple, sensitive method of screening for reduced hepatic function in birds. Galactose clearance and GEC-SA have the potential to be sensitive assays of hepatic functional mass, for use as a noninvasive method of monitoring hepatic function.

KW - Bile acids

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KW - Birds

KW - Eolophus roseicapillus

KW - Galactose clearance

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KW - Hepatectomy

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KW - Liver function tests

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VL - 14

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