Abstract
The in vitro antimalarial activities of artemisone and artemisone entrapped in Pheroid vesicles were compared, as was their ability to induce dormancy in Plasmodium falciparum. There was no increase in the activity of artemisone entrapped in Pheroid vesicles against multidrug-resistant P. falciparum lines. Artemisone induced the formation of dormant ring stages similar to dihydroartemisinin. Thus, the Pheroid delivery system neither improved the activity of artemisone nor prevented the induction of dormant rings.
Original language | English |
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Pages (from-to) | 7579-7582 |
Number of pages | 4 |
Journal | Antimicrobial Agents and Chemotherapy |
Volume | 58 |
Issue number | 12 |
DOIs | |
Publication status | Published - 01 Dec 2014 |