Association of cardiac autonomic neuropathy with alteration of sympatho-vagal balance through heart rate variability analysis

Ashan H. Khandoker, Herbert Jelinek, Toshio Moritani, Marimuthu Palaniswami

Research output: Contribution to journalArticlepeer-review

60 Citations (Scopus)


Early sub clinical assessment of severity of cardiac autonomic neuropathy (CAN) and intervention are of prime importance for risk stratification and early treatment in preventing sudden death due to silent myocardial infarction. The Ewing battery is currently the diagnostic tool of choice but is unable to detect subclinical disease and requires patient cooperation. Time and frequency domain analysis have several shortcomings including sensitivity to recording length, respiratory activity and non-stationarities in the ECG signal. An important step forward is to have a noninvasive method of detecting CAN that is robust against these shortcomings and has a higher sensitivity for the presence of both subclinical and overt clinical disease. This study presents a novel parameter, tone-entropy (T-E) that analyses heart rate variability (HRV) of 20 minute lead II ECG recordings. Tone (T) represents sympatho-vagal balance and Entropy (E) the autonomic regularity activity. Thirteen normal subjects without (CAN-) and 21 with CAN (CAN+) participated in this study. Among 21 CAN+ subjects, 13 are early CAN+ (eCAN+), eight are definite CAN+ (dCAN+) according to autonomic nervous system function tests as described by Ewing. The results showed that tone was higher and the entropy was lower in the dCAN+ group (T=-0.033 ~ -0.010 and E=1.73~2.24) compared with the eCAN+ (T= -0.0927 ~ -0.0311 and E=2.0~2.65) and normal (T= -0.128~ -0.0635 and E=2.64~3.15) group. The research verified that T-E is a suitable method to determine the presence of CAN that correctly identifies experimentally induced changes in cardiac function akin to parasympathetic and sympathetic dysfunction and differentiates between stages in CAN disease progression identified using the Ewing battery.
Original languageEnglish
Pages (from-to)161-167
Number of pages7
JournalMedical Engineering and Physics
Issue number2
Publication statusPublished - Mar 2010


Dive into the research topics of 'Association of cardiac autonomic neuropathy with alteration of sympatho-vagal balance through heart rate variability analysis'. Together they form a unique fingerprint.

Cite this