Abstract
Mycobacterium avium ssp. paratuberculosis (MAP) causes chronic enteritis in cattle that
results in substantial financial losses to the cattle industry worldwide. Given that
susceptibility to MAP infection is determined in part by genetics, marker-assisted selection
may help in the breeding of animals that are more resistant to MAP infection. The toll-like
receptor 4 gene (TLR4) was selected as a potential candidate gene because of its role in
innate immunity and its involvement in MAP recognition and infection. The objective of
this study, therefore, was to identify associations between TLR4 polymorphisms and
susceptibility to MAP infection in Canadian Holstein cows. Two biologically relevant SNPs,
including c.-226G>C in the 50
-untranslated region and the non-synonymous SNP
c.2021C>T in the potential TIR domain, were selected for an association analysis with
MAP infection status in 409 Canadian Holsteins. The haplotype C-T from these combined
SNPs yielded significant association with susceptibility to MAP infection, supporting the
involvement of TLR4 in susceptibility to MAP infection.
Original language | English |
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Pages (from-to) | 560-565 |
Number of pages | 6 |
Journal | Animal Genetics |
Volume | 46 |
Issue number | 5 |
DOIs | |
Publication status | Published - Oct 2015 |