ATP and luciferase assays to determine the rate of drug action in in vitro cultures of Plasmodium falciparum

Tasmiyah Khan, Anna C van Brummelen, Christopher Parkinson, Heinrich C. Hoppe

Research output: Contribution to journalArticle

10 Citations (Scopus)
8 Downloads (Pure)

Abstract

Knowledge of the rate of action of compounds against cultured malaria parasites is required to determine the optimal time-points for drug mode of action studies, as well as to predict likely in vivo parasite clearance rates in order to select optimal hit compounds for further development. In this study, changes in parasite ATP levels and transgenic luciferase reporter activity were explored as means to detect drug-induced stress in cultured parasites.
Original languageEnglish
Pages (from-to)369-380
Number of pages12
JournalMalaria Journal
Volume11
Publication statusPublished - 2012

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