Autologous bone marrow mononuclear cell implantation for intracerebral hemorrhage- a prospective clinical observation

Zhong-Min Li, Zhi-Ti Zhang, Chuan-Jun Guo, Feng-Jun Geng, Fu Qiang, Lexin Wang

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Abstract

BackgroundThis study was designed to assess the clinical effect of bone marrow mononuclear cells including mesenchymal stem cell (MSCs) in patients with intracerebral hemorrhage (ICH).MethodsOne hundred patients were divided into a study (n=60) or a control group (n=40). Bone marrow mononuclear cells from the same patient were injected to the perihemorrhage area in the base ganglia through an intracranial drainage tube 5.9days after ICH. National Institute Stroke Scale (NIHSSS) and Barthel index was used to assess neurologic impairment and daily activities, respectively, before and 6months after intervention.ResultsSix months after implantation, the NIHSS score in the study group was lower than in the control group (10.09±8.86 vs 14.35±10.14, P<0.01), whereas the Barthel scores were higher (57.39±23.51 vs 46.90±20.29, P<0.01). Neurological and functional improvement was observed in 52 (86.7%) of the study group patients, and in 17 (42.5%) of the control group patients (P=0.001). No allergic or other adverse effects were observed in the study group.ConclusionAutologous bone marrow mononuclear cell implantation reduced neurological impairment and improved activities of daily living in a selected group of ICH patients. Further studies are required to ascertain the long-term safety and efficacy of this treatment.
Original languageEnglish
Pages (from-to)72-76
Number of pages5
JournalClinical Neurology and Neurosurgery
Volume115
Issue number1
DOIs
Publication statusPublished - Jan 2013

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Cerebral Hemorrhage
Bone Marrow Cells
Observation
Control Groups
Activities of Daily Living
Mesenchymal Stromal Cells
Ganglia
Nervous System
Drainage
Stroke
Safety

Cite this

Li, Zhong-Min ; Zhang, Zhi-Ti ; Guo, Chuan-Jun ; Geng, Feng-Jun ; Qiang, Fu ; Wang, Lexin. / Autologous bone marrow mononuclear cell implantation for intracerebral hemorrhage- a prospective clinical observation. In: Clinical Neurology and Neurosurgery. 2013 ; Vol. 115, No. 1. pp. 72-76.
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abstract = "BackgroundThis study was designed to assess the clinical effect of bone marrow mononuclear cells including mesenchymal stem cell (MSCs) in patients with intracerebral hemorrhage (ICH).MethodsOne hundred patients were divided into a study (n=60) or a control group (n=40). Bone marrow mononuclear cells from the same patient were injected to the perihemorrhage area in the base ganglia through an intracranial drainage tube 5.9days after ICH. National Institute Stroke Scale (NIHSSS) and Barthel index was used to assess neurologic impairment and daily activities, respectively, before and 6months after intervention.ResultsSix months after implantation, the NIHSS score in the study group was lower than in the control group (10.09±8.86 vs 14.35±10.14, P<0.01), whereas the Barthel scores were higher (57.39±23.51 vs 46.90±20.29, P<0.01). Neurological and functional improvement was observed in 52 (86.7{\%}) of the study group patients, and in 17 (42.5{\%}) of the control group patients (P=0.001). No allergic or other adverse effects were observed in the study group.ConclusionAutologous bone marrow mononuclear cell implantation reduced neurological impairment and improved activities of daily living in a selected group of ICH patients. Further studies are required to ascertain the long-term safety and efficacy of this treatment.",
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Autologous bone marrow mononuclear cell implantation for intracerebral hemorrhage- a prospective clinical observation. / Li, Zhong-Min; Zhang, Zhi-Ti; Guo, Chuan-Jun; Geng, Feng-Jun; Qiang, Fu; Wang, Lexin.

In: Clinical Neurology and Neurosurgery, Vol. 115, No. 1, 01.2013, p. 72-76.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Autologous bone marrow mononuclear cell implantation for intracerebral hemorrhage- a prospective clinical observation

AU - Li, Zhong-Min

AU - Zhang, Zhi-Ti

AU - Guo, Chuan-Jun

AU - Geng, Feng-Jun

AU - Qiang, Fu

AU - Wang, Lexin

N1 - Imported on 12 Apr 2017 - DigiTool details were: month (773h) = January, 2013; Journal title (773t) = Clinical Neurology and Neurosurgery. ISSNs: 0303-8467;

PY - 2013/1

Y1 - 2013/1

N2 - BackgroundThis study was designed to assess the clinical effect of bone marrow mononuclear cells including mesenchymal stem cell (MSCs) in patients with intracerebral hemorrhage (ICH).MethodsOne hundred patients were divided into a study (n=60) or a control group (n=40). Bone marrow mononuclear cells from the same patient were injected to the perihemorrhage area in the base ganglia through an intracranial drainage tube 5.9days after ICH. National Institute Stroke Scale (NIHSSS) and Barthel index was used to assess neurologic impairment and daily activities, respectively, before and 6months after intervention.ResultsSix months after implantation, the NIHSS score in the study group was lower than in the control group (10.09±8.86 vs 14.35±10.14, P<0.01), whereas the Barthel scores were higher (57.39±23.51 vs 46.90±20.29, P<0.01). Neurological and functional improvement was observed in 52 (86.7%) of the study group patients, and in 17 (42.5%) of the control group patients (P=0.001). No allergic or other adverse effects were observed in the study group.ConclusionAutologous bone marrow mononuclear cell implantation reduced neurological impairment and improved activities of daily living in a selected group of ICH patients. Further studies are required to ascertain the long-term safety and efficacy of this treatment.

AB - BackgroundThis study was designed to assess the clinical effect of bone marrow mononuclear cells including mesenchymal stem cell (MSCs) in patients with intracerebral hemorrhage (ICH).MethodsOne hundred patients were divided into a study (n=60) or a control group (n=40). Bone marrow mononuclear cells from the same patient were injected to the perihemorrhage area in the base ganglia through an intracranial drainage tube 5.9days after ICH. National Institute Stroke Scale (NIHSSS) and Barthel index was used to assess neurologic impairment and daily activities, respectively, before and 6months after intervention.ResultsSix months after implantation, the NIHSS score in the study group was lower than in the control group (10.09±8.86 vs 14.35±10.14, P<0.01), whereas the Barthel scores were higher (57.39±23.51 vs 46.90±20.29, P<0.01). Neurological and functional improvement was observed in 52 (86.7%) of the study group patients, and in 17 (42.5%) of the control group patients (P=0.001). No allergic or other adverse effects were observed in the study group.ConclusionAutologous bone marrow mononuclear cell implantation reduced neurological impairment and improved activities of daily living in a selected group of ICH patients. Further studies are required to ascertain the long-term safety and efficacy of this treatment.

KW - Open access version available

KW - Bone marrow

KW - Intracerebral hemorrhage

KW - Mesenchymal stem cell

KW - Stroke

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EP - 76

JO - Psychiatria, neurologia, neurochirurgia

JF - Psychiatria, neurologia, neurochirurgia

SN - 0303-8467

IS - 1

ER -