Auxiliary-directed oxidation of ursolic acid by 'Ru'-porphyrins: Chemical modulation of cytotoxicity against tumor cell lines

Katsunori Tanaka, Kishor Mazumder, Eric R O Siwu, Satoshi Nozaki, Yasuyoshi Watanabe, Koichi Fukase

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Derivatization of ursolic acid, one of the natural ursene-type pentacyclic triterpenes, was investigated by the oxidation with dioxoruthenium(VI) tetraphenylporphyrins. Oxidation selectivity on the terpene structure was modulated by the auxiliaries introduced on the tetraphenylporphyrin. Chemical oxidation of the ursolic acid affected the cytotoxic activity against tumor cell lines.

Original languageEnglish
Pages (from-to)1756-1759
Number of pages4
JournalTetrahedron Letters
Volume53
Issue number14
DOIs
Publication statusPublished - 04 Apr 2012

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