B-Glucan triggers spondylarthritis and Crohn's disease-like Ileitis in SKG mice

Merja Ruutu; Gethin Thomas; Roland Steck; Mariapia A Degli-Esposti; Martin S Zinkernagel; Kylie Alexander; Jared Velasco; Geoffrey Strutton; Ai Tran; Helen Benham; Linda M Rehaume; Robert J Wilson; Kristine Kikly; Julian Davies; Allison R. Pettit; Matthew A Brown; Michael A McGuckin; Ranjeny Thomas

doi:10.1002/art.34423

B-Glucan triggers spondylarthritis and Crohn's disease-like Ileitis in SKG mice

Merja Ruutu, Gethin Thomas, Roland Steck, Mariapia A Degli-Esposti, Martin S Zinkernagel, Kylie Alexander, Jared Velasco, Geoffrey Strutton, Ai Tran, Helen Benham, Linda M Rehaume, Robert J Wilson, Kristine Kikly, Julian Davies, Allison R. Pettit, Matthew A Brown, Michael A McGuckin, Ranjeny Thomas

Research output: Contribution to journal › Article › peer-review

211 Citations (Scopus)

Abstract

The spondylarthritides (SpA), including ankylosing spondylitis (AS), psoriatic arthritis(PsA), reactive arthritis, and arthritis associated with inflammatory bowel disease, cause chronic inflammation of the large peripheral and axial joints, eyes, skin,ileum, and colon. Genetic studies reveal common candidate genes for AS, PsA, and Crohn’s disease, including IL23R, IL12B, STAT3, and CARD9, all of which are associated with interleukin-23 (IL-23) signaling downstream of the dectin 1 -glucan receptor.

Original language	English
Pages (from-to)	2211-2222
Number of pages	12
Journal	Arthritis and Rheumatology
Volume	64
Issue number	7
DOIs	https://doi.org/10.1002/art.34423
Publication status	Published - 2012

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Ruutu, M., Thomas, G., Steck, R., Degli-Esposti, M. A., Zinkernagel, M. S., Alexander, K., Velasco, J., Strutton, G., Tran, A., Benham, H., Rehaume, L. M., Wilson, R. J., Kikly, K., Davies, J., Pettit, A. R., Brown, M. A., McGuckin, M. A., & Thomas, R. (2012). B-Glucan triggers spondylarthritis and Crohn's disease-like Ileitis in SKG mice. Arthritis and Rheumatology, 64(7), 2211-2222. https://doi.org/10.1002/art.34423

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title = "B-Glucan triggers spondylarthritis and Crohn's disease-like Ileitis in SKG mice",

abstract = "The spondylarthritides (SpA), including ankylosing spondylitis (AS), psoriatic arthritis(PsA), reactive arthritis, and arthritis associated with inflammatory bowel disease, cause chronic inflammation of the large peripheral and axial joints, eyes, skin,ileum, and colon. Genetic studies reveal common candidate genes for AS, PsA, and Crohn{\textquoteright}s disease, including IL23R, IL12B, STAT3, and CARD9, all of which are associated with interleukin-23 (IL-23) signaling downstream of the dectin 1 -glucan receptor.",

author = "Merja Ruutu and Gethin Thomas and Roland Steck and Degli-Esposti, {Mariapia A} and Zinkernagel, {Martin S} and Kylie Alexander and Jared Velasco and Geoffrey Strutton and Ai Tran and Helen Benham and Rehaume, {Linda M} and Wilson, {Robert J} and Kristine Kikly and Julian Davies and Pettit, {Allison R.} and Brown, {Matthew A} and McGuckin, {Michael A} and Ranjeny Thomas",

note = "Includes bibliographical references",

year = "2012",

doi = "10.1002/art.34423",

language = "English",

volume = "64",

pages = "2211--2222",

journal = "Arthritis and Rheumatology",

issn = "2326-5191",

publisher = "Rede Euroamericana de Motricidade Humana",

number = "7",

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Ruutu, M, Thomas, G, Steck, R, Degli-Esposti, MA, Zinkernagel, MS, Alexander, K, Velasco, J, Strutton, G, Tran, A, Benham, H, Rehaume, LM, Wilson, RJ, Kikly, K, Davies, J, Pettit, AR, Brown, MA, McGuckin, MA & Thomas, R 2012, 'B-Glucan triggers spondylarthritis and Crohn's disease-like Ileitis in SKG mice', Arthritis and Rheumatology, vol. 64, no. 7, pp. 2211-2222. https://doi.org/10.1002/art.34423

TY - JOUR

T1 - B-Glucan triggers spondylarthritis and Crohn's disease-like Ileitis in SKG mice

AU - Ruutu, Merja

AU - Thomas, Gethin

AU - Steck, Roland

AU - Degli-Esposti, Mariapia A

AU - Zinkernagel, Martin S

AU - Alexander, Kylie

AU - Velasco, Jared

AU - Strutton, Geoffrey

AU - Tran, Ai

AU - Benham, Helen

AU - Rehaume, Linda M

AU - Wilson, Robert J

AU - Kikly, Kristine

AU - Davies, Julian

AU - Pettit, Allison R.

AU - Brown, Matthew A

AU - McGuckin, Michael A

AU - Thomas, Ranjeny

N1 - Includes bibliographical references

PY - 2012

Y1 - 2012

N2 - The spondylarthritides (SpA), including ankylosing spondylitis (AS), psoriatic arthritis(PsA), reactive arthritis, and arthritis associated with inflammatory bowel disease, cause chronic inflammation of the large peripheral and axial joints, eyes, skin,ileum, and colon. Genetic studies reveal common candidate genes for AS, PsA, and Crohn’s disease, including IL23R, IL12B, STAT3, and CARD9, all of which are associated with interleukin-23 (IL-23) signaling downstream of the dectin 1 -glucan receptor.

AB - The spondylarthritides (SpA), including ankylosing spondylitis (AS), psoriatic arthritis(PsA), reactive arthritis, and arthritis associated with inflammatory bowel disease, cause chronic inflammation of the large peripheral and axial joints, eyes, skin,ileum, and colon. Genetic studies reveal common candidate genes for AS, PsA, and Crohn’s disease, including IL23R, IL12B, STAT3, and CARD9, all of which are associated with interleukin-23 (IL-23) signaling downstream of the dectin 1 -glucan receptor.

U2 - 10.1002/art.34423

DO - 10.1002/art.34423

M3 - Article

SN - 2326-5191

VL - 64

SP - 2211

EP - 2222

JO - Arthritis and Rheumatology

JF - Arthritis and Rheumatology

IS - 7

ER -

B-Glucan triggers spondylarthritis and Crohn's disease-like Ileitis in SKG mice

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