Bacillus Calmette-Guérin vaccination reduces the severity and progression of tuberculosis in badgers

Mark A. Chambers; Fiona Rogers; Richard J. Delahay; Sandrine Lesellier; Roland Ashford; Deanna Dalley; Sonya Gowtage; Dipesh Davé; Si Palmer; Jacky Brewer; Timothy Crawshaw; Richard Clifton Hadley; Steve Carter; Chris Cheeseman; Chris Hanks; Alistair Murray; Kate Palphramand; Stéphane Pietravalle; Graham C. Smith; Alexandra Tomlinson; Neil J. Walker; Gavin J. Wilson; Leigh A.L. Corner; Stephen P. Rushton; Mark D.F. Shirley; George Gettinby; Robbie A. McDonald; R. Glyn Hewinson

doi:10.1098/rspb.2010.1953

Bacillus Calmette-Guérin vaccination reduces the severity and progression of tuberculosis in badgers

Mark A. Chambers, Fiona Rogers, Richard J. Delahay, Sandrine Lesellier, Roland Ashford, Deanna Dalley, Sonya Gowtage, Dipesh Davé, Si Palmer, Jacky Brewer, Timothy Crawshaw, Richard Clifton Hadley, Steve Carter, Chris Cheeseman, Chris Hanks, Alistair Murray, Kate Palphramand, Stéphane Pietravalle, Graham C. Smith, Alexandra TomlinsonNeil J. Walker, Gavin J. Wilson, Leigh A.L. Corner, Stephen P. Rushton, Mark D.F. Shirley, George Gettinby, Robbie A. McDonald, R. Glyn Hewinson

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Abstract

Control of bovine tuberculosis (TB) in cattle has proven particularly challenging where reservoirs of infection exist in wildlife populations. In Britain and Ireland, control is hampered by a reservoir of infection in Eurasian badgers (Meles meles). Badger culling has positive and negative effects on bovine TB in cattle and is difficult, costly and controversial. Here we show that Bacillus Calmette-Gue ́rin (BCG) vaccination of captive badgers reduced the progression, severity and excretion of Mycobacterium bovis infection after experimental challenge. In a clinical field study, BCG vaccination of free-living badgers reduced the incidence of positive serological test results by 73.8 per cent. In common with other species, BCG did not appear to prevent infection of badgers subjected to experimental challenge, but did significantly reduce the overall disease burden. BCG vaccination of badgers could comprise an important component of a comprehensive programme of measures to control bovine TB in cattle.

Original language	English
Pages (from-to)	1913-1920
Number of pages	8
Journal	Proceedings of the Royal Society B: Biological Sciences
Volume	278
Issue number	1713
DOIs	https://doi.org/10.1098/rspb.2010.1953
Publication status	Published - 01 Jun 2011

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Chambers, M. A., Rogers, F., Delahay, R. J., Lesellier, S., Ashford, R., Dalley, D., Gowtage, S., Davé, D., Palmer, S., Brewer, J., Crawshaw, T., Hadley, R. C., Carter, S., Cheeseman, C., Hanks, C., Murray, A., Palphramand, K., Pietravalle, S., Smith, G. C., ... Glyn Hewinson, R. (2011). Bacillus Calmette-Guérin vaccination reduces the severity and progression of tuberculosis in badgers. Proceedings of the Royal Society B: Biological Sciences, 278(1713), 1913-1920. https://doi.org/10.1098/rspb.2010.1953

@article{83a1e3b2b5334acfbfef85a0621e2afb,

title = "Bacillus Calmette-Gu{\'e}rin vaccination reduces the severity and progression of tuberculosis in badgers",

abstract = "Control of bovine tuberculosis (TB) in cattle has proven particularly challenging where reservoirs of infection exist in wildlife populations. In Britain and Ireland, control is hampered by a reservoir of infection in Eurasian badgers (Meles meles). Badger culling has positive and negative effects on bovine TB in cattle and is difficult, costly and controversial. Here we show that Bacillus Calmette-Gue{\' }rin (BCG) vaccination of captive badgers reduced the progression, severity and excretion of Mycobacterium bovis infection after experimental challenge. In a clinical field study, BCG vaccination of free-living badgers reduced the incidence of positive serological test results by 73.8 per cent. In common with other species, BCG did not appear to prevent infection of badgers subjected to experimental challenge, but did significantly reduce the overall disease burden. BCG vaccination of badgers could comprise an important component of a comprehensive programme of measures to control bovine TB in cattle.",

keywords = "Bacillus Calmette-Gu{\'e}rin, Badger, Bovine tuberculosis, Vaccination, Wildlife",

author = "Chambers, {Mark A.} and Fiona Rogers and Delahay, {Richard J.} and Sandrine Lesellier and Roland Ashford and Deanna Dalley and Sonya Gowtage and Dipesh Dav{\'e} and Si Palmer and Jacky Brewer and Timothy Crawshaw and Hadley, {Richard Clifton} and Steve Carter and Chris Cheeseman and Chris Hanks and Alistair Murray and Kate Palphramand and St{\'e}phane Pietravalle and Smith, {Graham C.} and Alexandra Tomlinson and Walker, {Neil J.} and Wilson, {Gavin J.} and Corner, {Leigh A.L.} and Rushton, {Stephen P.} and Shirley, {Mark D.F.} and George Gettinby and McDonald, {Robbie A.} and {Glyn Hewinson}, R.",

year = "2011",

month = jun,

day = "1",

doi = "10.1098/rspb.2010.1953",

language = "English",

volume = "278",

pages = "1913--1920",

journal = "Proceedings of the Royal Society B: Biological Sciences",

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Chambers, MA, Rogers, F, Delahay, RJ, Lesellier, S, Ashford, R, Dalley, D, Gowtage, S, Davé, D, Palmer, S, Brewer, J, Crawshaw, T, Hadley, RC, Carter, S, Cheeseman, C, Hanks, C, Murray, A, Palphramand, K, Pietravalle, S, Smith, GC, Tomlinson, A, Walker, NJ, Wilson, GJ, Corner, LAL, Rushton, SP, Shirley, MDF, Gettinby, G, McDonald, RA & Glyn Hewinson, R 2011, 'Bacillus Calmette-Guérin vaccination reduces the severity and progression of tuberculosis in badgers', Proceedings of the Royal Society B: Biological Sciences, vol. 278, no. 1713, pp. 1913-1920. https://doi.org/10.1098/rspb.2010.1953

TY - JOUR

T1 - Bacillus Calmette-Guérin vaccination reduces the severity and progression of tuberculosis in badgers

AU - Chambers, Mark A.

AU - Rogers, Fiona

AU - Delahay, Richard J.

AU - Lesellier, Sandrine

AU - Ashford, Roland

AU - Dalley, Deanna

AU - Gowtage, Sonya

AU - Davé, Dipesh

AU - Palmer, Si

AU - Brewer, Jacky

AU - Crawshaw, Timothy

AU - Hadley, Richard Clifton

AU - Carter, Steve

AU - Cheeseman, Chris

AU - Hanks, Chris

AU - Murray, Alistair

AU - Palphramand, Kate

AU - Pietravalle, Stéphane

AU - Smith, Graham C.

AU - Tomlinson, Alexandra

AU - Walker, Neil J.

AU - Wilson, Gavin J.

AU - Corner, Leigh A.L.

AU - Rushton, Stephen P.

AU - Shirley, Mark D.F.

AU - Gettinby, George

AU - McDonald, Robbie A.

AU - Glyn Hewinson, R.

PY - 2011/6/1

Y1 - 2011/6/1

N2 - Control of bovine tuberculosis (TB) in cattle has proven particularly challenging where reservoirs of infection exist in wildlife populations. In Britain and Ireland, control is hampered by a reservoir of infection in Eurasian badgers (Meles meles). Badger culling has positive and negative effects on bovine TB in cattle and is difficult, costly and controversial. Here we show that Bacillus Calmette-Gue ́rin (BCG) vaccination of captive badgers reduced the progression, severity and excretion of Mycobacterium bovis infection after experimental challenge. In a clinical field study, BCG vaccination of free-living badgers reduced the incidence of positive serological test results by 73.8 per cent. In common with other species, BCG did not appear to prevent infection of badgers subjected to experimental challenge, but did significantly reduce the overall disease burden. BCG vaccination of badgers could comprise an important component of a comprehensive programme of measures to control bovine TB in cattle.

AB - Control of bovine tuberculosis (TB) in cattle has proven particularly challenging where reservoirs of infection exist in wildlife populations. In Britain and Ireland, control is hampered by a reservoir of infection in Eurasian badgers (Meles meles). Badger culling has positive and negative effects on bovine TB in cattle and is difficult, costly and controversial. Here we show that Bacillus Calmette-Gue ́rin (BCG) vaccination of captive badgers reduced the progression, severity and excretion of Mycobacterium bovis infection after experimental challenge. In a clinical field study, BCG vaccination of free-living badgers reduced the incidence of positive serological test results by 73.8 per cent. In common with other species, BCG did not appear to prevent infection of badgers subjected to experimental challenge, but did significantly reduce the overall disease burden. BCG vaccination of badgers could comprise an important component of a comprehensive programme of measures to control bovine TB in cattle.

KW - Bacillus Calmette-Guérin

KW - Badger

KW - Bovine tuberculosis

KW - Vaccination

KW - Wildlife

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U2 - 10.1098/rspb.2010.1953

DO - 10.1098/rspb.2010.1953

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C2 - 21123260

AN - SCOPUS:79955785811

SN - 0962-8452

VL - 278

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EP - 1920

JO - Proceedings of the Royal Society B: Biological Sciences

JF - Proceedings of the Royal Society B: Biological Sciences

IS - 1713

ER -

Bacillus Calmette-Guérin vaccination reduces the severity and progression of tuberculosis in badgers

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