Beta-glucan triggers spondylarthritis and Crohn's disease-like ileitis in SKG mice

Merja Ruutu, Gethin Thomas, Roland Steck, Mariapia A Degli-Esposti, Martin S Zinkernagel, Kylie Alexander, Jared Velasco, Geoffrey Strutton, Ai Tran, Helen Benham, Linda M Rehaume, Robert J Wilson, Kristine Kikly, Julian Davies, Allison R. Pettit, Matthew A Brown, Michael A McGuckin, Ranjeny Thomas

    Research output: Contribution to journalArticle

    128 Citations (Scopus)

    Abstract

    The spondylarthritides (SpA), including ankylosing spondylitis (AS), psoriatic arthritis(PsA), reactive arthritis, and arthritis associated with inflammatory bowel disease, cause chronic inflammation of the large peripheral and axial joints, eyes, skin,ileum, and colon. Genetic studies reveal common candidate genes for AS, PsA, and Crohn’s disease, including IL23R, IL12B, STAT3, and CARD9, all of which are associated with interleukin-23 (IL-23) signaling downstream of the dectin 1 -glucan receptor.
    Original languageEnglish
    Pages (from-to)2211-2222
    Number of pages12
    JournalArthritis and Rheumatology
    Volume64
    Issue number7
    DOIs
    Publication statusPublished - 2012

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