I would like to report proof of concept of a novel application of PET/CT in insects. Understanding glucose metabolism in the honeybee provides an insight into phenotypic physiologic adaptations under varying stressful conditions. Bees require either stored honey or nectar to survive, with limitation to access being fatal within 24h. Various sugars can be used as a source in the absence of natural nutrition. The bee digests nutrients, which are circulated in the hemolymph to be used as energy or stored in the fat bodies, and varying levels of protein glycation occurs under different stress conditions.