Biophenols of mints: Antioxidant, acetylcholinesterase, butyrylcholinesterase and histone deacetylase inhibition activities targeting Alzheimer's disease treatment

Doaa M. Hanafy; Paul D. Prenzler; Geoffrey E. Burrows; Danielle Ryan; Sharon Nielsen; Salma A. El Sawi; Taha S. El Alfy; Enas H. Abdelrahman; Hassan K. Obied

doi:10.1016/j.jff.2017.03.027

Biophenols of mints: Antioxidant, acetylcholinesterase, butyrylcholinesterase and histone deacetylase inhibition activities targeting Alzheimer's disease treatment

Doaa M. Hanafy, Paul D. Prenzler, Geoffrey E. Burrows, Danielle Ryan, Sharon Nielsen, Salma A. El Sawi, Taha S. El Alfy, Enas H. Abdelrahman, Hassan K. Obied

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

Alzheimer's disease (AD) is a progressive age-related brain disorder that slowly destroys memory, with no cure for AD currently available. Plants from the Lamiaceae have been used traditionally for improving memory. Nineteen Mentha taxa were screened for in vitro antioxidant and acetyl- (AChE) and butyryl-cholinesterase (BuChE) and histone deacetylase (HDAC) inhibition activities. Total phenolic content was assessed, together with chromatographic determination of the phenolic composition. Two species, Mentha diemenica and M. requienii, were investigated for the first time. Mints showed strong antioxidant and moderate AChE and BuChE inhibition activities. Mint extracts exhibited good HDAC inhibition activity which was strongly correlated to their biophenol content. Apigenin-7-O-β-D-diglucuronide, chicoric acid and isosakuranetin were tentatively identified as new compounds in Mentha. Our results suggest that mints provide a substantial basis for future research into AD treatment. Furthermore, we highlight that biophenol composition and bioactivity can vary according to several factors within a single taxon.

Original language	English
Pages (from-to)	345-362
Number of pages	18
Journal	Journal of Functional Foods
Volume	33
DOIs	https://doi.org/10.1016/j.jff.2017.03.027
Publication status	Published - 01 Jun 2017

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Hanafy, D. M., Prenzler, P. D., Burrows, G. E., Ryan, D., Nielsen, S., El Sawi, S. A., El Alfy, T. S., Abdelrahman, E. H., & Obied, H. K. (2017). Biophenols of mints: Antioxidant, acetylcholinesterase, butyrylcholinesterase and histone deacetylase inhibition activities targeting Alzheimer's disease treatment. Journal of Functional Foods, 33, 345-362. https://doi.org/10.1016/j.jff.2017.03.027

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title = "Biophenols of mints: Antioxidant, acetylcholinesterase, butyrylcholinesterase and histone deacetylase inhibition activities targeting Alzheimer's disease treatment",

abstract = "Alzheimer's disease (AD) is a progressive age-related brain disorder that slowly destroys memory, with no cure for AD currently available. Plants from the Lamiaceae have been used traditionally for improving memory. Nineteen Mentha taxa were screened for in vitro antioxidant and acetyl- (AChE) and butyryl-cholinesterase (BuChE) and histone deacetylase (HDAC) inhibition activities. Total phenolic content was assessed, together with chromatographic determination of the phenolic composition. Two species, Mentha diemenica and M. requienii, were investigated for the first time. Mints showed strong antioxidant and moderate AChE and BuChE inhibition activities. Mint extracts exhibited good HDAC inhibition activity which was strongly correlated to their biophenol content. Apigenin-7-O-β-D-diglucuronide, chicoric acid and isosakuranetin were tentatively identified as new compounds in Mentha. Our results suggest that mints provide a substantial basis for future research into AD treatment. Furthermore, we highlight that biophenol composition and bioactivity can vary according to several factors within a single taxon.",

keywords = "Cholinesterase, Lamiaceae, Mentha, Mentha diemenica, Mentha requienii, Polyphenol",

author = "Hanafy, {Doaa M.} and Prenzler, {Paul D.} and Burrows, {Geoffrey E.} and Danielle Ryan and Sharon Nielsen and {El Sawi}, {Salma A.} and {El Alfy}, {Taha S.} and Abdelrahman, {Enas H.} and Obied, {Hassan K.}",

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year = "2017",

month = jun,

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doi = "10.1016/j.jff.2017.03.027",

language = "English",

volume = "33",

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journal = "Journal of Functional Foods",

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Hanafy, DM , Prenzler, PD , Burrows, GE , Ryan, D, Nielsen, S, El Sawi, SA, El Alfy, TS, Abdelrahman, EH & Obied, HK 2017, 'Biophenols of mints: Antioxidant, acetylcholinesterase, butyrylcholinesterase and histone deacetylase inhibition activities targeting Alzheimer's disease treatment', Journal of Functional Foods, vol. 33, pp. 345-362. https://doi.org/10.1016/j.jff.2017.03.027

TY - JOUR

T1 - Biophenols of mints

T2 - Antioxidant, acetylcholinesterase, butyrylcholinesterase and histone deacetylase inhibition activities targeting Alzheimer's disease treatment

AU - Hanafy, Doaa M.

AU - Prenzler, Paul D.

AU - Burrows, Geoffrey E.

AU - Ryan, Danielle

AU - Nielsen, Sharon

AU - El Sawi, Salma A.

AU - El Alfy, Taha S.

AU - Abdelrahman, Enas H.

AU - Obied, Hassan K.

N1 - Includes bibliographical references.

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Alzheimer's disease (AD) is a progressive age-related brain disorder that slowly destroys memory, with no cure for AD currently available. Plants from the Lamiaceae have been used traditionally for improving memory. Nineteen Mentha taxa were screened for in vitro antioxidant and acetyl- (AChE) and butyryl-cholinesterase (BuChE) and histone deacetylase (HDAC) inhibition activities. Total phenolic content was assessed, together with chromatographic determination of the phenolic composition. Two species, Mentha diemenica and M. requienii, were investigated for the first time. Mints showed strong antioxidant and moderate AChE and BuChE inhibition activities. Mint extracts exhibited good HDAC inhibition activity which was strongly correlated to their biophenol content. Apigenin-7-O-β-D-diglucuronide, chicoric acid and isosakuranetin were tentatively identified as new compounds in Mentha. Our results suggest that mints provide a substantial basis for future research into AD treatment. Furthermore, we highlight that biophenol composition and bioactivity can vary according to several factors within a single taxon.

AB - Alzheimer's disease (AD) is a progressive age-related brain disorder that slowly destroys memory, with no cure for AD currently available. Plants from the Lamiaceae have been used traditionally for improving memory. Nineteen Mentha taxa were screened for in vitro antioxidant and acetyl- (AChE) and butyryl-cholinesterase (BuChE) and histone deacetylase (HDAC) inhibition activities. Total phenolic content was assessed, together with chromatographic determination of the phenolic composition. Two species, Mentha diemenica and M. requienii, were investigated for the first time. Mints showed strong antioxidant and moderate AChE and BuChE inhibition activities. Mint extracts exhibited good HDAC inhibition activity which was strongly correlated to their biophenol content. Apigenin-7-O-β-D-diglucuronide, chicoric acid and isosakuranetin were tentatively identified as new compounds in Mentha. Our results suggest that mints provide a substantial basis for future research into AD treatment. Furthermore, we highlight that biophenol composition and bioactivity can vary according to several factors within a single taxon.

KW - Cholinesterase

KW - Lamiaceae

KW - Mentha

KW - Mentha diemenica

KW - Mentha requienii

KW - Polyphenol

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DO - 10.1016/j.jff.2017.03.027

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AN - SCOPUS:85017305590

SN - 1756-4646

VL - 33

SP - 345

EP - 362

JO - Journal of Functional Foods

JF - Journal of Functional Foods

ER -

Biophenols of mints: Antioxidant, acetylcholinesterase, butyrylcholinesterase and histone deacetylase inhibition activities targeting Alzheimer's disease treatment

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