Biosensing made easy with PEG-targeted bi-specific antibodies

Lyndon J. Raftery, Yadveer S. Grewal, Christopher B. Howard, Martina L. Jones, Muhammad J.A. Shiddiky, Laura G. Carrascosa, Kristofer J. Thurecht, Stephen M. Mahler, Matt Trau

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Whilst recent advances in nanotechnology have yielded many new biosensing capabilities, innovative biological attachment and detection modalities remain relatively underdeveloped. Bi-specific antibodies (bsAbs) - which exhibit binding capability for two separate targets - offer an inherent advantage over conventional antibody reagents by significantly simplifying sensor surface preparation. Herein, we report the deployment of bsAbs for simultaneous attachment to a polymer-coated transducer and label-free, electrochemical (EC) detection of target antigens.

Original languageEnglish
Pages (from-to)5730-5733
Number of pages4
JournalChemical Communications
Volume52
Issue number33
DOIs
Publication statusPublished - 28 Apr 2016

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