Blood concentrations of omega-3 in participants with juvenile bipolar disorder compared to healthy controls

Edward Clayton, Tanya L. Hanstock, Stephen J. Hirneth, Colin J. Kable, Manohar L. Garg, Philip L. Hazell

Research output: Book chapter/Published conference paperConference paper


Background: A deficiency of long-chain omega-3 polyunsaturated fatty acids (LCn-3PUFA), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), has been reported in adults with depression and bipolar disorder (BD). Aims: To examine LCn-3PUFA status in children and adolescents with juvenile BD (JBD) compared to healthy controls and the relationship with symptoms of mania and depression. Method: Fifteen participants (9-18 yrs) with JBD and fifteen age and sex-matched controls were assessed for dietary intake and red blood cell (RBC) LCn-3PUFA. Results: RBC EPA and DHA were significantly lower in participants with JBD compared to controls, but not after controlling for LCn-3PUFA intake. RBC DHA was also negatively related to clinician ratings of depression and participant ratings of aggression. Conclusion: Lower RBC LCn-3PUFA in JBD was explained by lower intakes in the current study. Given previous evidence linking deficiencies of LCn-3PUFA to BD, a randomised placebo-controlled study examining supplementation with LCn-3PUFA as an adjunct to standard pharmacotherapy appears warranted in this participant population.
Original languageEnglish
Title of host publicationAustralasian Society of Psychiatric Research
EditorsPeter Joyce
Place of PublicationLondon
PublisherInforma Healthcare USA
PagesA45 (OP041)
Publication statusPublished - 2008
EventAustralian and New Zealand Journal of Psychiatry - Newcastle
Duration: 02 Dec 200805 Dec 2008


ConferenceAustralian and New Zealand Journal of Psychiatry

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