Blood concentrations of omega-3 in participants with juvenile bipolar disorder compared to healthy controls

Edward Clayton; Tanya L. Hanstock; Stephen J. Hirneth; Colin J. Kable; Manohar L. Garg; Philip L. Hazell

Blood concentrations of omega-3 in participants with juvenile bipolar disorder compared to healthy controls

Edward Clayton, Tanya L. Hanstock, Stephen J. Hirneth, Colin J. Kable, Manohar L. Garg, Philip L. Hazell

Research output: Book chapter/Published conference paper › Conference paper › peer-review

Abstract

Background: A deficiency of long-chain omega-3 polyunsaturated fatty acids (LCn-3PUFA), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), has been reported in adults with depression and bipolar disorder (BD). Aims: To examine LCn-3PUFA status in children and adolescents with juvenile BD (JBD) compared to healthy controls and the relationship with symptoms of mania and depression. Method: Fifteen participants (9-18 yrs) with JBD and fifteen age and sex-matched controls were assessed for dietary intake and red blood cell (RBC) LCn-3PUFA. Results: RBC EPA and DHA were significantly lower in participants with JBD compared to controls, but not after controlling for LCn-3PUFA intake. RBC DHA was also negatively related to clinician ratings of depression and participant ratings of aggression. Conclusion: Lower RBC LCn-3PUFA in JBD was explained by lower intakes in the current study. Given previous evidence linking deficiencies of LCn-3PUFA to BD, a randomised placebo-controlled study examining supplementation with LCn-3PUFA as an adjunct to standard pharmacotherapy appears warranted in this participant population.

Original language	English
Title of host publication	Australasian Society of Psychiatric Research
Editors	Peter Joyce
Place of Publication	London
Publisher	Informa Healthcare USA
Pages	A45 (OP041)
Volume	42
Publication status	Published - 2008
Event	Australian and New Zealand Journal of Psychiatry - Newcastle Duration: 02 Dec 2008 → 05 Dec 2008

Conference

Conference	Australian and New Zealand Journal of Psychiatry
Period	02/12/08 → 05/12/08

Cite this

@inproceedings{a646bed29e514c85a3e9f8afa96ba2f6,

title = "Blood concentrations of omega-3 in participants with juvenile bipolar disorder compared to healthy controls",

abstract = "Background: A deficiency of long-chain omega-3 polyunsaturated fatty acids (LCn-3PUFA), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), has been reported in adults with depression and bipolar disorder (BD). Aims: To examine LCn-3PUFA status in children and adolescents with juvenile BD (JBD) compared to healthy controls and the relationship with symptoms of mania and depression. Method: Fifteen participants (9-18 yrs) with JBD and fifteen age and sex-matched controls were assessed for dietary intake and red blood cell (RBC) LCn-3PUFA. Results: RBC EPA and DHA were significantly lower in participants with JBD compared to controls, but not after controlling for LCn-3PUFA intake. RBC DHA was also negatively related to clinician ratings of depression and participant ratings of aggression. Conclusion: Lower RBC LCn-3PUFA in JBD was explained by lower intakes in the current study. Given previous evidence linking deficiencies of LCn-3PUFA to BD, a randomised placebo-controlled study examining supplementation with LCn-3PUFA as an adjunct to standard pharmacotherapy appears warranted in this participant population.",

keywords = "Blood, Juvenile Bipolar Disorder, Omega-3",

author = "Edward Clayton and Hanstock, {Tanya L.} and Hirneth, {Stephen J.} and Kable, {Colin J.} and Garg, {Manohar L.} and Hazell, {Philip L.}",

note = "Imported on 03 May 2017 - DigiTool details were: publisher = London: Informa healthcare, 2008. editor/s (773b) = Peter Joyce; Event dates (773o) = 2-5 December 2008; Parent title (773t) = Australian and New Zealand Journal of Psychiatry. ISSNs: 0004-8674; ; Australian and New Zealand Journal of Psychiatry ; Conference date: 02-12-2008 Through 05-12-2008",

year = "2008",

language = "English",

volume = "42",

pages = "A45 (OP041)",

editor = "Peter Joyce",

booktitle = "Australasian Society of Psychiatric Research",

publisher = "Informa Healthcare USA",

address = "United Kingdom",

}

Blood concentrations of omega-3 in participants with juvenile bipolar disorder compared to healthy controls. / Clayton, Edward; Hanstock, Tanya L.; Hirneth, Stephen J. et al.
Australasian Society of Psychiatric Research. ed. / Peter Joyce. Vol. 42 London: Informa Healthcare USA, 2008. p. A45 (OP041).

Research output: Book chapter/Published conference paper › Conference paper › peer-review

TY - GEN

T1 - Blood concentrations of omega-3 in participants with juvenile bipolar disorder compared to healthy controls

AU - Clayton, Edward

AU - Hanstock, Tanya L.

AU - Hirneth, Stephen J.

AU - Kable, Colin J.

AU - Garg, Manohar L.

AU - Hazell, Philip L.

N1 - Imported on 03 May 2017 - DigiTool details were: publisher = London: Informa healthcare, 2008. editor/s (773b) = Peter Joyce; Event dates (773o) = 2-5 December 2008; Parent title (773t) = Australian and New Zealand Journal of Psychiatry. ISSNs: 0004-8674;

PY - 2008

Y1 - 2008

N2 - Background: A deficiency of long-chain omega-3 polyunsaturated fatty acids (LCn-3PUFA), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), has been reported in adults with depression and bipolar disorder (BD). Aims: To examine LCn-3PUFA status in children and adolescents with juvenile BD (JBD) compared to healthy controls and the relationship with symptoms of mania and depression. Method: Fifteen participants (9-18 yrs) with JBD and fifteen age and sex-matched controls were assessed for dietary intake and red blood cell (RBC) LCn-3PUFA. Results: RBC EPA and DHA were significantly lower in participants with JBD compared to controls, but not after controlling for LCn-3PUFA intake. RBC DHA was also negatively related to clinician ratings of depression and participant ratings of aggression. Conclusion: Lower RBC LCn-3PUFA in JBD was explained by lower intakes in the current study. Given previous evidence linking deficiencies of LCn-3PUFA to BD, a randomised placebo-controlled study examining supplementation with LCn-3PUFA as an adjunct to standard pharmacotherapy appears warranted in this participant population.

AB - Background: A deficiency of long-chain omega-3 polyunsaturated fatty acids (LCn-3PUFA), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), has been reported in adults with depression and bipolar disorder (BD). Aims: To examine LCn-3PUFA status in children and adolescents with juvenile BD (JBD) compared to healthy controls and the relationship with symptoms of mania and depression. Method: Fifteen participants (9-18 yrs) with JBD and fifteen age and sex-matched controls were assessed for dietary intake and red blood cell (RBC) LCn-3PUFA. Results: RBC EPA and DHA were significantly lower in participants with JBD compared to controls, but not after controlling for LCn-3PUFA intake. RBC DHA was also negatively related to clinician ratings of depression and participant ratings of aggression. Conclusion: Lower RBC LCn-3PUFA in JBD was explained by lower intakes in the current study. Given previous evidence linking deficiencies of LCn-3PUFA to BD, a randomised placebo-controlled study examining supplementation with LCn-3PUFA as an adjunct to standard pharmacotherapy appears warranted in this participant population.

KW - Blood

KW - Juvenile Bipolar Disorder

KW - Omega-3

M3 - Conference paper

VL - 42

SP - A45 (OP041)

BT - Australasian Society of Psychiatric Research

A2 - Joyce, Peter

PB - Informa Healthcare USA

CY - London

T2 - Australian and New Zealand Journal of Psychiatry

Y2 - 2 December 2008 through 5 December 2008

ER -

Blood concentrations of omega-3 in participants with juvenile bipolar disorder compared to healthy controls

Abstract

Conference

Fingerprint

Cite this