c-Fos transrepression revisited

Research output: Contribution to journalArticlepeer-review


The c-fos proto-oncogene was discovered by homology to transforming viral genes, leading to speculation that transforming viruses had captured a cellular gene involved in cell cycle control. Indeed overexpression of c-Fos protein led to deregulated growth control, and c-Fos was thought to be so critically involved in cell cycle control that transcriptional transrepression of its own promoter was interpreted as a negative feedback mechanism. However, recent findings render this conclusion improbable, Fos transrepression being most parsimoniously explained as transcriptional squelching imposed by artificially elevated levels of exogenous Fos protein.

Original languageEnglish
Pages (from-to)9-10
Number of pages2
JournalFEBS Letters
Issue number1
Publication statusPublished - 02 Jan 1997


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