Cardiac lymphatic interruption is a major cause for allograft failure after cardiac transplantation

Xiang-quan Kong, Lexin Wang, Dequi Kong

Research output: Contribution to journalArticle

20 Citations (Scopus)
5 Downloads (Pure)

Abstract

Cardiac transplantation is one of the most effective treatments of end stage heart failure to date, although it comes with risks. One of the major complications of cardiac transplantation is allograft failure, which is caused by ischemic injuries, pulmonary hypertension and chronic rejection. Recent animal and human studies have demonstrated that cardiac lymphatic obstruction leads to significant myocardial fibrosis and depression in contractile forces. We hypothesize that lymphatic interruption, which is almost inevitable after cardiac transplantation, is a major cause of cardiac allograft failure through direct damages to the myocardium and also through the formation of allograft coronary vasculopathy.
Original languageEnglish
Pages (from-to)45-48
Number of pages4
JournalLymphatic Research and Biology
Volume5
Issue number1
DOIs
Publication statusPublished - 2007

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Heart Transplantation
Allografts
Heart Failure
Pulmonary Hypertension
Myocardium
Fibrosis
Wounds and Injuries

Cite this

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abstract = "Cardiac transplantation is one of the most effective treatments of end stage heart failure to date, although it comes with risks. One of the major complications of cardiac transplantation is allograft failure, which is caused by ischemic injuries, pulmonary hypertension and chronic rejection. Recent animal and human studies have demonstrated that cardiac lymphatic obstruction leads to significant myocardial fibrosis and depression in contractile forces. We hypothesize that lymphatic interruption, which is almost inevitable after cardiac transplantation, is a major cause of cardiac allograft failure through direct damages to the myocardium and also through the formation of allograft coronary vasculopathy.",
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Cardiac lymphatic interruption is a major cause for allograft failure after cardiac transplantation. / Kong, Xiang-quan; Wang, Lexin; Kong, Dequi.

In: Lymphatic Research and Biology, Vol. 5, No. 1, 2007, p. 45-48.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cardiac lymphatic interruption is a major cause for allograft failure after cardiac transplantation

AU - Kong, Xiang-quan

AU - Wang, Lexin

AU - Kong, Dequi

N1 - Imported on 12 Apr 2017 - DigiTool details were: Journal title (773t) = Lymphatic Research and Biology. ISSNs: 1539-6851;

PY - 2007

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AB - Cardiac transplantation is one of the most effective treatments of end stage heart failure to date, although it comes with risks. One of the major complications of cardiac transplantation is allograft failure, which is caused by ischemic injuries, pulmonary hypertension and chronic rejection. Recent animal and human studies have demonstrated that cardiac lymphatic obstruction leads to significant myocardial fibrosis and depression in contractile forces. We hypothesize that lymphatic interruption, which is almost inevitable after cardiac transplantation, is a major cause of cardiac allograft failure through direct damages to the myocardium and also through the formation of allograft coronary vasculopathy.

KW - Open access version available

KW - Allograft failure

KW - Cardiac lymphatics

KW - Cardiac transplantation

KW - Coronary vasculopathy

KW - Ischemia

U2 - 10.1089/lrb.2007.5108

DO - 10.1089/lrb.2007.5108

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