Cardiac troponin 1: a review

Heather Duffy, Tony Moore, Nicholas Car

Research output: Contribution to journalArticlepeer-review

Abstract

Cardiac troponin I is a powerful tool to aid in the diagnosis of myocardial infarction and cardiac muscle damage, and is widely used in clinical practice. It is currently one of the best cardiac markers for a definitive diagnosis, with positive results being highly indicative of myocardial damage. The troponin I molecule is highly complex in nature, causing difficulties in ensuring comparable results across the many immunoassay platforms currently in use. Many factors can influence antigen recognition by different antibodies, and an urgent issue for troponin I measurements is the development of an international standard. Until adequate standardization exists, reference values and clinical thresholds need to be determined separately for each assay platform. Acceptance of individual troponin I assays should be based on peer-reviewed literature, and clinical studies should provide information pertaining to an assay's imprecision, reference intervals, potential analytical interferences and acceptable specimen types for this sensitive and reliable marker of cardiac damage.
Original languageEnglish
Pages (from-to)67-76
Number of pages10
JournalAustralian Journal of Medical Science
Volume25
Issue number2
Publication statusPublished - 2004

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