Cardiovascular disease risk factors in a Nigerian population with impaired fasting blood glucose level and diabetes mellitus

Victor Maduabuchi Oguoma, Ezekiel U. Nwose, Ifeoma I Ulasi, Adeseye A Akintunde, Ekene E Chukwukelu, Phillip T. Bwititi, Ross S. Richards, Timothy Chas Skinner

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Abstract

Background: Diabetes is a risk factor for cardiovascular diseases (CVDs) and there are reports of increasing prevalence of prediabetes in Nigeria. This study therefore characterised CVDs risk factors in subjects with impaired fasting glucose (IFG) and diabetes. Methods: Data from 4 population-based cross-sectional studies on 2447 apparently healthy individuals from 18 - 89 years were analysed. Anthropometric, blood pressure and biochemical parameters were collected and classified. Individuals with IFG (prediabetes) and diabetes were merged each for positive cases of dyslipidaemia, high blood pressure (HBP) or obesity. Optimal Discriminant and Hierarchical Optimal Classification Tree Analysis (HO-CTA) were employed. Results: Overall prevalence of IFG and diabetes were 5.8% (CI: 4.9 - 6.7%) and 3.1% (CI: 2.4 - 3.8%), respectively. IFG co-morbidity with dyslipidaemia (5.0%; CI: 4.1 - 5.8%) was the highest followed by overweight/obese (3.1%; CI: 2.5 - 3.8%) and HBP (1.8%; CI: 1.3 - 2.4%). The predicted age of IFG or diabetes and their co-morbidity with other CVD risk factors were between 40 - 45 years. Elevated blood level of total cholesterol was the most predictive co-morbid risk factor among IFG and diabetes subjects. Hypertriglyceridaemia was an important risk factor among IFG-normocholesterolaemic-overweight/obese individuals. Conclusion: The higher prevalence of co-morbidity of CVD risk factors with IFG than in diabetes plus the similar age of co-morbidity between IFG and diabetes highlights the need for risk assessment models for prediabetes and education of individuals at risk about factors that mitigate development of diabetes and CVDs.

Original languageEnglish
Article number36
Pages (from-to)1-9
Number of pages9
JournalBMC Public Health
Volume17
Issue number1
DOIs
Publication statusPublished - 06 Jan 2017

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Blood Glucose
Fasting
Diabetes Mellitus
Cardiovascular Diseases
Glucose
Population
Prediabetic State
Morbidity
Dyslipidemias
Hypertension
Needs Assessment
Hypertriglyceridemia
Nigeria
Obesity
Cross-Sectional Studies
Cholesterol
Blood Pressure
Education

Cite this

Oguoma, Victor Maduabuchi ; Nwose, Ezekiel U. ; Ulasi, Ifeoma I ; Akintunde, Adeseye A ; Chukwukelu, Ekene E ; Bwititi, Phillip T. ; Richards, Ross S. ; Skinner, Timothy Chas. / Cardiovascular disease risk factors in a Nigerian population with impaired fasting blood glucose level and diabetes mellitus. In: BMC Public Health. 2017 ; Vol. 17, No. 1. pp. 1-9.
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abstract = "Background: Diabetes is a risk factor for cardiovascular diseases (CVDs) and there are reports of increasing prevalence of prediabetes in Nigeria. This study therefore characterised CVDs risk factors in subjects with impaired fasting glucose (IFG) and diabetes. Methods: Data from 4 population-based cross-sectional studies on 2447 apparently healthy individuals from 18 - 89 years were analysed. Anthropometric, blood pressure and biochemical parameters were collected and classified. Individuals with IFG (prediabetes) and diabetes were merged each for positive cases of dyslipidaemia, high blood pressure (HBP) or obesity. Optimal Discriminant and Hierarchical Optimal Classification Tree Analysis (HO-CTA) were employed. Results: Overall prevalence of IFG and diabetes were 5.8{\%} (CI: 4.9 - 6.7{\%}) and 3.1{\%} (CI: 2.4 - 3.8{\%}), respectively. IFG co-morbidity with dyslipidaemia (5.0{\%}; CI: 4.1 - 5.8{\%}) was the highest followed by overweight/obese (3.1{\%}; CI: 2.5 - 3.8{\%}) and HBP (1.8{\%}; CI: 1.3 - 2.4{\%}). The predicted age of IFG or diabetes and their co-morbidity with other CVD risk factors were between 40 - 45 years. Elevated blood level of total cholesterol was the most predictive co-morbid risk factor among IFG and diabetes subjects. Hypertriglyceridaemia was an important risk factor among IFG-normocholesterolaemic-overweight/obese individuals. Conclusion: The higher prevalence of co-morbidity of CVD risk factors with IFG than in diabetes plus the similar age of co-morbidity between IFG and diabetes highlights the need for risk assessment models for prediabetes and education of individuals at risk about factors that mitigate development of diabetes and CVDs.",
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Cardiovascular disease risk factors in a Nigerian population with impaired fasting blood glucose level and diabetes mellitus. / Oguoma, Victor Maduabuchi; Nwose, Ezekiel U.; Ulasi, Ifeoma I; Akintunde, Adeseye A; Chukwukelu, Ekene E; Bwititi, Phillip T.; Richards, Ross S.; Skinner, Timothy Chas.

In: BMC Public Health, Vol. 17, No. 1, 36, 06.01.2017, p. 1-9.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cardiovascular disease risk factors in a Nigerian population with impaired fasting blood glucose level and diabetes mellitus

AU - Oguoma, Victor Maduabuchi

AU - Nwose, Ezekiel U.

AU - Ulasi, Ifeoma I

AU - Akintunde, Adeseye A

AU - Chukwukelu, Ekene E

AU - Bwititi, Phillip T.

AU - Richards, Ross S.

AU - Skinner, Timothy Chas

N1 - Includes bibliographical references.

PY - 2017/1/6

Y1 - 2017/1/6

N2 - Background: Diabetes is a risk factor for cardiovascular diseases (CVDs) and there are reports of increasing prevalence of prediabetes in Nigeria. This study therefore characterised CVDs risk factors in subjects with impaired fasting glucose (IFG) and diabetes. Methods: Data from 4 population-based cross-sectional studies on 2447 apparently healthy individuals from 18 - 89 years were analysed. Anthropometric, blood pressure and biochemical parameters were collected and classified. Individuals with IFG (prediabetes) and diabetes were merged each for positive cases of dyslipidaemia, high blood pressure (HBP) or obesity. Optimal Discriminant and Hierarchical Optimal Classification Tree Analysis (HO-CTA) were employed. Results: Overall prevalence of IFG and diabetes were 5.8% (CI: 4.9 - 6.7%) and 3.1% (CI: 2.4 - 3.8%), respectively. IFG co-morbidity with dyslipidaemia (5.0%; CI: 4.1 - 5.8%) was the highest followed by overweight/obese (3.1%; CI: 2.5 - 3.8%) and HBP (1.8%; CI: 1.3 - 2.4%). The predicted age of IFG or diabetes and their co-morbidity with other CVD risk factors were between 40 - 45 years. Elevated blood level of total cholesterol was the most predictive co-morbid risk factor among IFG and diabetes subjects. Hypertriglyceridaemia was an important risk factor among IFG-normocholesterolaemic-overweight/obese individuals. Conclusion: The higher prevalence of co-morbidity of CVD risk factors with IFG than in diabetes plus the similar age of co-morbidity between IFG and diabetes highlights the need for risk assessment models for prediabetes and education of individuals at risk about factors that mitigate development of diabetes and CVDs.

AB - Background: Diabetes is a risk factor for cardiovascular diseases (CVDs) and there are reports of increasing prevalence of prediabetes in Nigeria. This study therefore characterised CVDs risk factors in subjects with impaired fasting glucose (IFG) and diabetes. Methods: Data from 4 population-based cross-sectional studies on 2447 apparently healthy individuals from 18 - 89 years were analysed. Anthropometric, blood pressure and biochemical parameters were collected and classified. Individuals with IFG (prediabetes) and diabetes were merged each for positive cases of dyslipidaemia, high blood pressure (HBP) or obesity. Optimal Discriminant and Hierarchical Optimal Classification Tree Analysis (HO-CTA) were employed. Results: Overall prevalence of IFG and diabetes were 5.8% (CI: 4.9 - 6.7%) and 3.1% (CI: 2.4 - 3.8%), respectively. IFG co-morbidity with dyslipidaemia (5.0%; CI: 4.1 - 5.8%) was the highest followed by overweight/obese (3.1%; CI: 2.5 - 3.8%) and HBP (1.8%; CI: 1.3 - 2.4%). The predicted age of IFG or diabetes and their co-morbidity with other CVD risk factors were between 40 - 45 years. Elevated blood level of total cholesterol was the most predictive co-morbid risk factor among IFG and diabetes subjects. Hypertriglyceridaemia was an important risk factor among IFG-normocholesterolaemic-overweight/obese individuals. Conclusion: The higher prevalence of co-morbidity of CVD risk factors with IFG than in diabetes plus the similar age of co-morbidity between IFG and diabetes highlights the need for risk assessment models for prediabetes and education of individuals at risk about factors that mitigate development of diabetes and CVDs.

KW - Co-morbidity

KW - CVD risk factors

KW - Diabetes

KW - Impaired fasting glucose

KW - Nigeria

KW - Prediabetes

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