Catalysed oxygenation of allylic hydroperoxides derived from qinghao (artemisinic) acid. Conversion of qinghao acid into dehydroginghaosu (artemisitene) and qinghaosu (artemisinin)

Richard K. Haynes, Simone C. Vonwiller

Research output: Contribution to journalArticlepeer-review

78 Citations (Scopus)

Abstract

Photo-oxygenation of ginghao acid and its dihydro analogue provides allylic hydroperoxides which are converted either indirectly via the corresponding esters, or directly into dehydroginghaosu (artemisitene) and the antimalarial ginghaosu (artemisinin), by treatment with a catalytic amount of copper(II) trifluoromethanesulphonate with or without an iron(III) co-catalyst in dichloromethane-acetonitrile under oxygen.

Original languageEnglish
Pages (from-to)451-453
Number of pages3
JournalJournal of the Chemical Society, Chemical Communications
Issue number6
DOIs
Publication statusPublished - 1990

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