Cathepsin B proteases of flukes: the key to facilitating parasite control?

Peter M. Smooker, Rama Jayaraj, Robert N. Pike, Terry Spithill

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Cysteine proteases are important virulence factors for parasites. This review will focus on the cathepsin B proteases of trematodes (also known as flukes) which are abundant in juvenile and immature flukes. Recent research, primarily in Fasciola, using inhibitors, RNA interference (RNAi) and vaccination studies indicates that cathepsin Bs play a key role in the biology of trematodes. As these proteases are largely expressed by infective parasite stages, their inactivation by chemotherapy or vaccination will greatly reduce the damage wrought by flukes as they invade host tissues. This validates cathepsin Bs as key strategic targets for fluke control.
Original languageEnglish
Pages (from-to)506-514
Number of pages9
JournalTrends in Parasitology
Volume26
Issue number10
DOIs
Publication statusPublished - Oct 2010

Fingerprint Dive into the research topics of 'Cathepsin B proteases of flukes: the key to facilitating parasite control?'. Together they form a unique fingerprint.

  • Cite this