Cell contact dependent extended release of adenovirus by microparticles in vitro

Heather Cavanagh, Daniel Dingwall, Jason Steel, James Benson, Mark Burton

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Adenoviral vectors remain one of the most promising methods of gene delivery but are plagued by several inherent problems including immune inactivation and transient expression. This paper reports a novel microparticle-based delivery system for adenovirus that allows high uptake of virus, stable complex formation and extended release. In addition, this microparticle/adenovirus complex has been demonstrated to only release virus upon cell contact. The significant clinical implications of this delivery system are discussed.
Original languageEnglish
Pages (from-to)57-64
Number of pages8
JournalJournal of Virological Methods
Volume95
Issue number1-2
DOIs
Publication statusPublished - 2001

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