Cell contact dependent extended release of adenovirus by microparticles in vitro

Heather Cavanagh; Daniel Dingwall; Jason Steel; James Benson; Mark Burton

doi:10.1016/S0166-0934(01)00291-9

Cell contact dependent extended release of adenovirus by microparticles in vitro

Heather Cavanagh
, Daniel Dingwall
, Jason Steel
, James Benson
, Mark Burton

Science and Health

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Adenoviral vectors remain one of the most promising methods of gene delivery but are plagued by several inherent problems including immune inactivation and transient expression. This paper reports a novel microparticle-based delivery system for adenovirus that allows high uptake of virus, stable complex formation and extended release. In addition, this microparticle/adenovirus complex has been demonstrated to only release virus upon cell contact. The significant clinical implications of this delivery system are discussed.

Original language	English
Pages (from-to)	57-64
Number of pages	8
Journal	Journal of Virological Methods
Volume	95
Issue number	1-2
DOIs	https://doi.org/10.1016/S0166-0934(01)00291-9
Publication status	Published - 2001

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10.1016/S0166-0934(01)00291-9

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title = "Cell contact dependent extended release of adenovirus by microparticles in vitro",

abstract = "Adenoviral vectors remain one of the most promising methods of gene delivery but are plagued by several inherent problems including immune inactivation and transient expression. This paper reports a novel microparticle-based delivery system for adenovirus that allows high uptake of virus, stable complex formation and extended release. In addition, this microparticle/adenovirus complex has been demonstrated to only release virus upon cell contact. The significant clinical implications of this delivery system are discussed.",

author = "Heather Cavanagh and Daniel Dingwall and Jason Steel and James Benson and Mark Burton",

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AU - Cavanagh, Heather

AU - Dingwall, Daniel

AU - Steel, Jason

AU - Benson, James

AU - Burton, Mark

N1 - Imported on 12 Apr 2017 - DigiTool details were: Journal title (773t) = Journal of Virological Methods. ISSNs: 0166-0934;

PY - 2001

Y1 - 2001

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AB - Adenoviral vectors remain one of the most promising methods of gene delivery but are plagued by several inherent problems including immune inactivation and transient expression. This paper reports a novel microparticle-based delivery system for adenovirus that allows high uptake of virus, stable complex formation and extended release. In addition, this microparticle/adenovirus complex has been demonstrated to only release virus upon cell contact. The significant clinical implications of this delivery system are discussed.

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DO - 10.1016/S0166-0934(01)00291-9

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VL - 95

SP - 57

EP - 64

JO - Journal of Virological Methods

JF - Journal of Virological Methods

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ER -

Cell contact dependent extended release of adenovirus by microparticles in vitro

Abstract

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