Central nervous system activity of the methanol extracts of Helianthus annuus seeds in mice model

Rubab Islam, Ahmed Tanjimul Islam, Mir Hossain, Kishor Mazumder

Research output: Contribution to journalArticle

Abstract

Helianthus annuus seeds contain various chemical components and evaluate different biological activities. The present study was carried out to investigate the central nervous system (CNS) activity of methanolic extract of Helianthus annuus seeds in mice model. General behaviour, antidepressant activity and anxiolytic activity was observed. The results revealed that the methanol extract of Helianthus annuus seeds at 100 and 200 mg/kg caused a significant increase in the spontaneous activity (general behavioural profile), moderate increase in anxiolytic activity (light-dark box and elevated plus maze test) and remarkable increase in antidepressant activity (tail suspension test). The results suggest that methanol extract of Helianthus annuus exhibit significant antidepressant and moderate anxiolytic activity in tested animal models.


Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalInternational Current Pharmaceutical Journal, December
Volume5
Issue number1
DOIs
Publication statusPublished - Dec 2015

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