A wide range of health benefits have been attributed to cereal bioactive compounds known as polyphenols. However due to their low plasma concentrations after consumption there is controversy regarding the therapeutic benefits. Within the gastrointestinal tract, some cereal polyphenols are absorbed in the small intestine, with majority accumulating and metabolised by gut microbiota in the colon. The interactions between the cereal polyphenols and the gut is believed to promote gut health and modulate the concentrations and bioactivity in plasma. This project will employ simulated in vitro gastrointestinal digestion coupled with an intestinal monolayer cell culture model in order to investigate the impact on the metabolism, antioxidant activity and absorption of the polyphenols. The cytoprotective effects of cereal phenolic extracts will be evaluated in vitro followed by a human clinical trial in order to evaluate the impact of supplementation on the gut microbiome and the anti-inflammatory and antioxidant status of plasma.
|Number of pages||1|
|Publication status||Published - 24 Aug 2020|
|Event||Faculty of Science Higher Degree by Research and Honours Symposium 2020 - Online|
Duration: 26 Aug 2020 → 04 Sept 2020
https://cdn.csu.edu.au/__data/assets/pdf_file/0003/3535815/FOS-symposium-flyer.pdf (Symposium flyer)
|Conference||Faculty of Science Higher Degree by Research and Honours Symposium 2020|
|Period||26/08/20 → 04/09/20|
|Other||Welcome to the first online Faculty of Science Higher Degree Research and Honours Symposium!|
The online Symposium is an opportunity for research students in the Faculty of Science to present their research to their peers in a conference setting and to receive valuable feedback. It is also an opportunity to
attend professional development workshops.
There is an extraordinary variety of research being undertaken within our Faculty and this breadth will be showcased during the Symposium. Our research investigates fundamental human needs such as food and
water, through to the health of both humans and the environment. It is exciting to be able to present an online Symposium that offers such a diversity of both quantitative and qualitative research.