TY - JOUR
T1 - Changes in pharmacokinetics in the elderly and therapeutic drug monitoring of antiarrhythmic drugs
AU - Wang, Lexin
N1 - Imported on 12 Apr 2017 - DigiTool details were: Journal title (773t) = Life Science Journal. ISSNs: 1097-8135;
PY - 2007
Y1 - 2007
N2 - Advanced-age is associated with significant changes in physiological functions and absorption, distribution, metabolism and elimination of drugs. Antiarrhythmic drugs are traditionally classified into four classes, according to Vaughan Williams’s classification. The renal and hepatic elimination of many antiarrhythmic drug classes are reduced in the elderly, predisposing this population to serious drug adverse effects. Therapeutic drug monitoring has been a useful clinical tool in the safe use of antiarrhythmic drugs, especially class I drugs and amiodarone, in the younger population. Given the changes in pharmacokinetics of antiarrhythmic drugs and increased risk of adverse effects in older patients, therapeutic drug monitoring may be of particularly importance for dosage adjustment and optimization of individual antiarrhythmic therapy in the elderly.
AB - Advanced-age is associated with significant changes in physiological functions and absorption, distribution, metabolism and elimination of drugs. Antiarrhythmic drugs are traditionally classified into four classes, according to Vaughan Williams’s classification. The renal and hepatic elimination of many antiarrhythmic drug classes are reduced in the elderly, predisposing this population to serious drug adverse effects. Therapeutic drug monitoring has been a useful clinical tool in the safe use of antiarrhythmic drugs, especially class I drugs and amiodarone, in the younger population. Given the changes in pharmacokinetics of antiarrhythmic drugs and increased risk of adverse effects in older patients, therapeutic drug monitoring may be of particularly importance for dosage adjustment and optimization of individual antiarrhythmic therapy in the elderly.
KW - Open access version available
KW - Antiarrhythmic drugs
KW - Therapeutic drug monitoring, pharmacokinetics, aging
M3 - Article
VL - 42
SP - 1
EP - 7
JO - Life Science Journal
JF - Life Science Journal
SN - 1097-8135
IS - 2
ER -