Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 935-939 |
| Number of pages | 5 |
| Journal | Food Chemistry |
| Volume | 240 |
| Early online date | Jul 2017 |
| DOIs | |
| Publication status | Published - Feb 2018 |
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Channel directed rutin nano-encapsulation in phytoferritin induced by guanidine hydrochloride. / Yang, Rui; Liu, Yuqian; Blanchard, Christopher; Zhou, Zhongkai.
In: Food Chemistry, Vol. 240, 02.2018, p. 935-939.Research output: Contribution to journal › Article
TY - JOUR
T1 - Channel directed rutin nano-encapsulation in phytoferritin induced by guanidine hydrochloride
AU - Yang, Rui
AU - Liu, Yuqian
AU - Blanchard, Christopher
AU - Zhou, Zhongkai
N1 - Includes bibliographical references.
PY - 2018/2
Y1 - 2018/2
N2 - Phytoferritin cage has a nano-sized cavity to encapsulate bioactive molecules. In this work, a novel approach is presented that guanidine hydrochloride (GuHCl) (2mM) can expand the channel of apo-soybean seed ferritin (apoSSF) and promote the encapsulation of rutin molecules in apoSSF at pH 7.0 without the disassembly of the protein cage. Upon removal of GuHCl from SSF, a rutin encapsulation ratio of 10.1% was obtained; and the prepared rutin-loaded ferritin nanoparticles were homogeneously distributed, showing a shell-like morphology with a size of 12nm. By virtue of this interesting method, core molecules can be encapsulated within the ferritin cage in a benign condition without extreme pH changes, which is beneficial for the stability and bioactivity of the pH-sensitive molecules in food encapsulation and delivery of functional molecules.
AB - Phytoferritin cage has a nano-sized cavity to encapsulate bioactive molecules. In this work, a novel approach is presented that guanidine hydrochloride (GuHCl) (2mM) can expand the channel of apo-soybean seed ferritin (apoSSF) and promote the encapsulation of rutin molecules in apoSSF at pH 7.0 without the disassembly of the protein cage. Upon removal of GuHCl from SSF, a rutin encapsulation ratio of 10.1% was obtained; and the prepared rutin-loaded ferritin nanoparticles were homogeneously distributed, showing a shell-like morphology with a size of 12nm. By virtue of this interesting method, core molecules can be encapsulated within the ferritin cage in a benign condition without extreme pH changes, which is beneficial for the stability and bioactivity of the pH-sensitive molecules in food encapsulation and delivery of functional molecules.
KW - Nano-encapsulation
KW - Guanidine hydrochloride
KW - Protein channel
KW - Ferritin cage
U2 - 10.1016/j.foodchem.2017.07.088
DO - 10.1016/j.foodchem.2017.07.088
M3 - Article
C2 - 28946364
VL - 240
SP - 935
EP - 939
JO - Journal of Micronutrient Analysis
JF - Journal of Micronutrient Analysis
SN - 0308-8146
ER -