Characterization of porcine milk oligosaccharides over lactation between primiparous and multiparous female pigs

Jinhua Wei, Zhuo A. Wang , Bing Wang, Marefa Jahan, Zhongfu Wang, Peter Wynn, Yuguang Du

Research output: Contribution to journalArticle

3 Citations (Scopus)
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Abstract

Milk oligosaccharides (MOs) are complex carbohydrates with multifunctional health benefits for the neonate. Poor reproductive performance in primiparous gilts limits their productivity. Changes in the structure and abundance of porcine MO (PMOs) through lactation with parity remains unknown and may explain superior new-born growth in litters from multiparous sows relative to gilts. We report 55 PMOs structures, of which 25 are new (17 sialylated and 8 neutral). Their incidence in gilt and sow colostrum was almost identical (53 vs. 54), but not in transitional milk (48 vs. 53) nor mature milk (41 vs. 47). These PMOs including neutral-, sialyl- and fucosyl- MOs in colostrum were more abundant in the gilt than the sow, but always decreased during lactation. Structural diversity decreased, although fucosylated MO were conserved. In conclusion, high diversity and levels of MO in porcine milk is parity dependent. Given the similarity between porcine and human MO profiles, our findings may help define key roles for MOs as potential dietary additives to improve growth of neonates from first pregnancies in both human and sows.
Original languageEnglish
Article number4688
Pages (from-to)1-16
Number of pages6
JournalScientific Reports
Volume8
DOIs
Publication statusPublished - Mar 2018

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oligosaccharides
lactation
milk
swine
gilts
sows
parity (reproduction)
colostrum
neonates
breast milk
litters (young animals)
reproductive performance
pregnancy
carbohydrates
incidence

Cite this

@article{bec0253f68a149ffa6d39c64a91a16ee,
title = "Characterization of porcine milk oligosaccharides over lactation between primiparous and multiparous female pigs",
abstract = "Milk oligosaccharides (MOs) are complex carbohydrates with multifunctional health benefits for the neonate. Poor reproductive performance in primiparous gilts limits their productivity. Changes in the structure and abundance of porcine MO (PMOs) through lactation with parity remains unknown and may explain superior new-born growth in litters from multiparous sows relative to gilts. We report 55 PMOs structures, of which 25 are new (17 sialylated and 8 neutral). Their incidence in gilt and sow colostrum was almost identical (53 vs. 54), but not in transitional milk (48 vs. 53) nor mature milk (41 vs. 47). These PMOs including neutral-, sialyl- and fucosyl- MOs in colostrum were more abundant in the gilt than the sow, but always decreased during lactation. Structural diversity decreased, although fucosylated MO were conserved. In conclusion, high diversity and levels of MO in porcine milk is parity dependent. Given the similarity between porcine and human MO profiles, our findings may help define key roles for MOs as potential dietary additives to improve growth of neonates from first pregnancies in both human and sows.",
author = "Jinhua Wei and Wang, {Zhuo A.} and Bing Wang and Marefa Jahan and Zhongfu Wang and Peter Wynn and Yuguang Du",
year = "2018",
month = "3",
doi = "10.1038/s41598-018-23025-x",
language = "English",
volume = "8",
pages = "1--16",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

Characterization of porcine milk oligosaccharides over lactation between primiparous and multiparous female pigs. / Wei, Jinhua; Wang , Zhuo A.; Wang, Bing; Jahan, Marefa; Wang, Zhongfu ; Wynn, Peter; Du, Yuguang.

In: Scientific Reports, Vol. 8, 4688, 03.2018, p. 1-16.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Characterization of porcine milk oligosaccharides over lactation between primiparous and multiparous female pigs

AU - Wei, Jinhua

AU - Wang , Zhuo A.

AU - Wang, Bing

AU - Jahan, Marefa

AU - Wang, Zhongfu

AU - Wynn, Peter

AU - Du, Yuguang

PY - 2018/3

Y1 - 2018/3

N2 - Milk oligosaccharides (MOs) are complex carbohydrates with multifunctional health benefits for the neonate. Poor reproductive performance in primiparous gilts limits their productivity. Changes in the structure and abundance of porcine MO (PMOs) through lactation with parity remains unknown and may explain superior new-born growth in litters from multiparous sows relative to gilts. We report 55 PMOs structures, of which 25 are new (17 sialylated and 8 neutral). Their incidence in gilt and sow colostrum was almost identical (53 vs. 54), but not in transitional milk (48 vs. 53) nor mature milk (41 vs. 47). These PMOs including neutral-, sialyl- and fucosyl- MOs in colostrum were more abundant in the gilt than the sow, but always decreased during lactation. Structural diversity decreased, although fucosylated MO were conserved. In conclusion, high diversity and levels of MO in porcine milk is parity dependent. Given the similarity between porcine and human MO profiles, our findings may help define key roles for MOs as potential dietary additives to improve growth of neonates from first pregnancies in both human and sows.

AB - Milk oligosaccharides (MOs) are complex carbohydrates with multifunctional health benefits for the neonate. Poor reproductive performance in primiparous gilts limits their productivity. Changes in the structure and abundance of porcine MO (PMOs) through lactation with parity remains unknown and may explain superior new-born growth in litters from multiparous sows relative to gilts. We report 55 PMOs structures, of which 25 are new (17 sialylated and 8 neutral). Their incidence in gilt and sow colostrum was almost identical (53 vs. 54), but not in transitional milk (48 vs. 53) nor mature milk (41 vs. 47). These PMOs including neutral-, sialyl- and fucosyl- MOs in colostrum were more abundant in the gilt than the sow, but always decreased during lactation. Structural diversity decreased, although fucosylated MO were conserved. In conclusion, high diversity and levels of MO in porcine milk is parity dependent. Given the similarity between porcine and human MO profiles, our findings may help define key roles for MOs as potential dietary additives to improve growth of neonates from first pregnancies in both human and sows.

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