Chemically attenuated Plasmodium sporozoites induce specific immune responses, sterile immunity and cross-protection against heterologous challenge

Lisa Purcell, Kurt Wong, Stephanie Yanow, Moses Lee, Terry Spithill, Ana Rodriguez

    Research output: Contribution to journalArticlepeer-review

    49 Citations (Scopus)

    Abstract

    Vaccination with Plasmodium sporozoites attenuated by irradiation or genetic manipulation induces a protective immune response in rodent malaria models. Recently, vaccination with chemically attenuated P. berghei sporozoites (CAS) has also been shown to elicit sterile immunity in mice. Here we show that vaccination with CAS of P. yoelii also protects against homologous infection and that a P. berghei CAS vaccinecross protects against heterologous challenge with P. yoelii sporozoites. Vaccination with P. yoelii orP. berghei CAS induced parasite-specific antibodies and IFN-y-producing CD8+ T cells at levels not significantly different from radiation-attenuated sporozoites. Our findings provide an initial characterization of the immune response generated by CAS vaccination and suggest that this attenuation process could be used in the production of an effective cross-protective liver stage vaccine for malaria.
    Original languageEnglish
    Pages (from-to)4880-4884
    Number of pages5
    JournalVaccine
    Volume26
    Issue number38
    DOIs
    Publication statusPublished - 2008

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