Chemopreventive potential of cereal polyphenols

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

It has been identified that diet is one of the major contributing factors associated with the development of cancer and other chronic pathologies. In the recent years, supplementing regular diet with food and/or its components that contain chemopreventive properties has been considered an effective approach in reducing the incidence of cancer and other lifestyle associated diseases. This systematic review provides an exhaustive summary of the chemopreventive properties exhibited by everyday dietary ingredients such as rice, barley, oats, and sorghum. The studies both in vitro and in vitro reviewed have highlighted the potential role of their polyphenolic content as chemopreventive agents. Polyphenolic compounds including anthocyanins, tricin, protocatechualdehyde, avenanthramide, and 3-deoxyanthocyanins found in rice, barley, oats, and sorghum, respectively, were identified as compounds with potent bioactivity. Studies demonstrated that cereal polyphenols are likely to have chemopreventive activities, particularly those found in pigmented varieties. In conclusion, findings suggest that the consumption of pigmented cereals could potentially have an important role as a natural complementary cancer preventive therapeutic. However, further studies to develop a complete understanding of the mechanisms by which phenolic compounds inhibit cancerous cell proliferation are warranted.
Original languageEnglish
Pages (from-to)913-927
Number of pages15
JournalNutrition and Cancer: an international journal
Volume70
Issue number6
Early online date01 Oct 2018
DOIs
Publication statusPublished - 2018

Fingerprint

Polyphenols
Sorghum
Hordeum
Diet
Neoplasms
Anthocyanins
Life Style
Cell Proliferation
Pathology
Food
Incidence
Edible Grain
In Vitro Techniques
Oryza
Avena
Therapeutics

Cite this

@article{ef1a9ecebea8469784eb03b6eeb79c4b,
title = "Chemopreventive potential of cereal polyphenols",
abstract = "It has been identified that diet is one of the major contributing factors associated with the development of cancer and other chronic pathologies. In the recent years, supplementing regular diet with food and/or its components that contain chemopreventive properties has been considered an effective approach in reducing the incidence of cancer and other lifestyle associated diseases. This systematic review provides an exhaustive summary of the chemopreventive properties exhibited by everyday dietary ingredients such as rice, barley, oats, and sorghum. The studies both in vitro and in vitro reviewed have highlighted the potential role of their polyphenolic content as chemopreventive agents. Polyphenolic compounds including anthocyanins, tricin, protocatechualdehyde, avenanthramide, and 3-deoxyanthocyanins found in rice, barley, oats, and sorghum, respectively, were identified as compounds with potent bioactivity. Studies demonstrated that cereal polyphenols are likely to have chemopreventive activities, particularly those found in pigmented varieties. In conclusion, findings suggest that the consumption of pigmented cereals could potentially have an important role as a natural complementary cancer preventive therapeutic. However, further studies to develop a complete understanding of the mechanisms by which phenolic compounds inhibit cancerous cell proliferation are warranted.",
keywords = "Oryza-Sativa L., black rice anthocyanins, Nitric-oxide production, fermented brown rice, aberrant crypt foci, cancer cell-lines, NF-KAPPA B, Sorghum-Bicolor, Antioxidant activity, Anticancer activity",
author = "Shiwangni Rao and Abishek Santhakumar and Kenneth Chinkwo and Thirumahal Vanniasinkam and Jixun Luo and Christopher Blanchard",
year = "2018",
doi = "10.1080/01635581.2018.1491609",
language = "English",
volume = "70",
pages = "913--927",
journal = "Nutrition and Cancer: an international journal",
issn = "0163-5581",
publisher = "Routledge",
number = "6",

}

TY - JOUR

T1 - Chemopreventive potential of cereal polyphenols

AU - Rao, Shiwangni

AU - Santhakumar, Abishek

AU - Chinkwo, Kenneth

AU - Vanniasinkam, Thirumahal

AU - Luo, Jixun

AU - Blanchard, Christopher

PY - 2018

Y1 - 2018

N2 - It has been identified that diet is one of the major contributing factors associated with the development of cancer and other chronic pathologies. In the recent years, supplementing regular diet with food and/or its components that contain chemopreventive properties has been considered an effective approach in reducing the incidence of cancer and other lifestyle associated diseases. This systematic review provides an exhaustive summary of the chemopreventive properties exhibited by everyday dietary ingredients such as rice, barley, oats, and sorghum. The studies both in vitro and in vitro reviewed have highlighted the potential role of their polyphenolic content as chemopreventive agents. Polyphenolic compounds including anthocyanins, tricin, protocatechualdehyde, avenanthramide, and 3-deoxyanthocyanins found in rice, barley, oats, and sorghum, respectively, were identified as compounds with potent bioactivity. Studies demonstrated that cereal polyphenols are likely to have chemopreventive activities, particularly those found in pigmented varieties. In conclusion, findings suggest that the consumption of pigmented cereals could potentially have an important role as a natural complementary cancer preventive therapeutic. However, further studies to develop a complete understanding of the mechanisms by which phenolic compounds inhibit cancerous cell proliferation are warranted.

AB - It has been identified that diet is one of the major contributing factors associated with the development of cancer and other chronic pathologies. In the recent years, supplementing regular diet with food and/or its components that contain chemopreventive properties has been considered an effective approach in reducing the incidence of cancer and other lifestyle associated diseases. This systematic review provides an exhaustive summary of the chemopreventive properties exhibited by everyday dietary ingredients such as rice, barley, oats, and sorghum. The studies both in vitro and in vitro reviewed have highlighted the potential role of their polyphenolic content as chemopreventive agents. Polyphenolic compounds including anthocyanins, tricin, protocatechualdehyde, avenanthramide, and 3-deoxyanthocyanins found in rice, barley, oats, and sorghum, respectively, were identified as compounds with potent bioactivity. Studies demonstrated that cereal polyphenols are likely to have chemopreventive activities, particularly those found in pigmented varieties. In conclusion, findings suggest that the consumption of pigmented cereals could potentially have an important role as a natural complementary cancer preventive therapeutic. However, further studies to develop a complete understanding of the mechanisms by which phenolic compounds inhibit cancerous cell proliferation are warranted.

KW - Oryza-Sativa L.

KW - black rice anthocyanins

KW - Nitric-oxide production

KW - fermented brown rice

KW - aberrant crypt foci

KW - cancer cell-lines

KW - NF-KAPPA B

KW - Sorghum-Bicolor

KW - Antioxidant activity

KW - Anticancer activity

U2 - 10.1080/01635581.2018.1491609

DO - 10.1080/01635581.2018.1491609

M3 - Review article

C2 - 30273076

VL - 70

SP - 913

EP - 927

JO - Nutrition and Cancer: an international journal

JF - Nutrition and Cancer: an international journal

SN - 0163-5581

IS - 6

ER -