Chondrogenic potential of physically treated bovine cartilage matrix derived porous scaffolds on human dermal fibroblast cells

Ali Moradi, Forough Ataollahi, Katayoun Sayar, Sumit Pramanik, Pan-Pan Chong, Alizan Abdul Khalil, Tunku Kamarul, Belinda Pingguan-Murphy

    Research output: Contribution to journalArticlepeer-review

    17 Citations (Scopus)

    Abstract

    Extracellular matrices have drawn attention in tissue engineering as potential biomaterials for scaffold fabrication because of their bioactive components. Noninvasive techniques of scaffold fabrication and cross-linking treatments are believed to maintain the integrity of bioactive molecules while providing proper architectural and mechanical properties. Cartilage matrix derived scaffolds are designed to support the maintenance of chondrocytes and provide proper signals for differentiation of chondroinducible cells. Chondroinductive potential of bovine articular cartilage matrix derived porous scaffolds on human dermal fibroblasts and the effect of scaffold shrinkage on chondrogenesis were investigated. An increase in sulfated glycosaminoglycans production along with upregulation of chondrogenic genes confirmed that physically treated cartilage matrix derived scaffolds have chondrogenic potential on human dermal fibroblasts.
    Original languageEnglish
    Pages (from-to)245-256
    Number of pages12
    JournalJournal of Biomedical Materials Research - Part A
    Volume104
    Issue number1
    Early online dateSep 2015
    DOIs
    Publication statusPublished - 2016

    Fingerprint

    Dive into the research topics of 'Chondrogenic potential of physically treated bovine cartilage matrix derived porous scaffolds on human dermal fibroblast cells'. Together they form a unique fingerprint.

    Cite this