Choose your partners for the next dance: Implied PGRMC1 roles in membrane trafficking and mitochondrial modulation

Research output: Contribution to journalArticlepeer-review

Abstract

This commentary considers the study by Salsano et al. (1) while integrating implications from other very recent work.Progesterone (P4) receptor membrane component (PGRMC)1 is a multifunctional cytochrome b5 (Cytb5) domain protein.It is completely unrelated to the classic/nuclear P4 receptor (P4R). Its steroid-related biology is perhaps a billion years older. Nuclear steroid receptors, including P4R, did not appear until early in chordate evolution, whereas PGRMC1-family proteins regulate sterol synthesis from yeast to mammals (2)(see literature cited in the bibliographies of the cited references for some concepts discussed in this article due to citation limitations) and can confer progestogen responsiveness to, e.g., bilaterian animals that synthesize no P4.
Original languageEnglish
Pages (from-to)938-941
Number of pages4
JournalFertility and Sterility
Volume113
Issue number5
DOIs
Publication statusPublished - May 2020

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