TY - JOUR
T1 - Choose your partners for the next dance
T2 - Implied PGRMC1 roles in membrane trafficking and mitochondrial modulation
AU - Cahill, Michael A
PY - 2020/5
Y1 - 2020/5
N2 - This commentary considers the study by Salsano et al. (1) while integrating implications from other very recent work.Progesterone (P4) receptor membrane component (PGRMC)1 is a multifunctional cytochrome b5 (Cytb5) domain protein.It is completely unrelated to the classic/nuclear P4 receptor (P4R). Its steroid-related biology is perhaps a billion years older. Nuclear steroid receptors, including P4R, did not appear until early in chordate evolution, whereas PGRMC1-family proteins regulate sterol synthesis from yeast to mammals (2)(see literature cited in the bibliographies of the cited references for some concepts discussed in this article due to citation limitations) and can confer progestogen responsiveness to, e.g., bilaterian animals that synthesize no P4.
AB - This commentary considers the study by Salsano et al. (1) while integrating implications from other very recent work.Progesterone (P4) receptor membrane component (PGRMC)1 is a multifunctional cytochrome b5 (Cytb5) domain protein.It is completely unrelated to the classic/nuclear P4 receptor (P4R). Its steroid-related biology is perhaps a billion years older. Nuclear steroid receptors, including P4R, did not appear until early in chordate evolution, whereas PGRMC1-family proteins regulate sterol synthesis from yeast to mammals (2)(see literature cited in the bibliographies of the cited references for some concepts discussed in this article due to citation limitations) and can confer progestogen responsiveness to, e.g., bilaterian animals that synthesize no P4.
U2 - 10.1016/j.fertnstert.2020.01.029
DO - 10.1016/j.fertnstert.2020.01.029
M3 - Article
C2 - 32386619
VL - 113
SP - 938
EP - 941
JO - Fertility and Sterility
JF - Fertility and Sterility
SN - 0015-0282
IS - 5
ER -