Chronic high dose captopril decreases total heart rate variability and increases heart rate in C57BL/6J mice

F Touma, V.S.P. Chew, W.C. Chua, Herbert Jelinek, P.T. Wong, I. Spence, Craig McLachlan

Research output: Contribution to journalArticle

3 Citations (Scopus)
11 Downloads (Pure)

Abstract

The effects of high dose captopril, within the therapeutic range, on autonomic activity are unknown in those with normal cardiovascular function. Thus the study aims were to assess the effects of high dose captopril on autonomic function in mice. Autonomic activity was measured using heart rate variability (HRV). ECG recordings were obtained from 18 Male C57BL/6J mice (20-25g) subdivided into control (N=8) or mice receiving oral captopril (0.688mg/ml captopril in the drinking water for 6 weeks, N=10). HRV results for linear and non-linear parameters were attenuated following chronic captopril for 6 weeks compared to control. Captopril was associated with a trend for an increase in average heart rate and approximate entropy (ApEn), a nonlinear measure of HRV decreased significantly compared to control (p<0.05). In conclusion high dose captopril reduces total HRV and increases heart rate in normotensive mice with normal cardiac function.
Original languageEnglish
Pages (from-to)211-213
Number of pages3
JournalInternational Journal of Cardiology
Volume136
Issue number2
DOIs
Publication statusPublished - 2009

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