Circoviruses evolve more slowly than their hosts

Research output: Other contribution to conferenceAbstract

Abstract

Emerging evidence of endogenous viral elements in host genomes hints towards much older host-virus relationships than predicted by exogenous phylogenies. Resolving the long-term evolutionary history of vertebrate virus-host association and determining the age of a potentially ancient tree based only fresh shoots at the tips is problematic, especially when purifying selection or recombination significantly alters the accuracy of phylogenetic reconstruction methods. Pathogens which occupy entangled multispecies ecological niches add a further layer of complexity but these multi-host scenarios may also provide opportunities to identify allopatric orsympatric paleobiological signals that can unlock longer term phylogenies. Circoviruses are highly mutable single-stranded DNA (ssDNA) viruses with a high rate of genetic admixture through recombination, particularly in beak and feather disease virus (BFDV) which provides an excellent model for studying multi-host scenarios with host-switching events. We generated whole genome circoviral sequences from Australian psittacine birds and analysed those using phylogenetic reconstruction and population genetics approach to infer the macroevolutionary scenario. Endogenous circoviral motifs in kea (Nestor notabilis) with Gondwanan vicariance estimates were used to calibrate the evolutionary timescale. We identified host-based, cryptic, sympatric differentiation in BFDV in the Psittaciforme tribe Loriini with 10 million year divergence coinciding with the Papuan central range orogeny that triggered the radiation of Loriini and segregation of an antecedent viral clade in Australian lorikeets. We also demonstrated a chronology of circovirus speciation in birds highlighting a Gondwanan dominant group in Neoaves with passerine, columbid and larid circoviruses deeply separated from those in waterfowl, consistent with a Triassic divergence of Galloanserae. The circovirus tree had a deep ancestry in invertebrates with a Palaeozoic expansion in fish and mammals. We show how a virus that mutates rapidly might also retain phenotypic stability and wait millennia to change hosts or become a recognisable new virus species, a process that could lag well behind the evolution of the potential hosts.
Original languageEnglish
Number of pages1
Publication statusPublished - 2016
EventAustralian Society for Microbiology Annual Scientific Meeting and Exhibition (ASM 2016) - Perth, Australia, Australia
Duration: 03 Jul 201606 Jul 2016

Exhibition

ExhibitionAustralian Society for Microbiology Annual Scientific Meeting and Exhibition (ASM 2016)
CountryAustralia
Period03/07/1606/07/16

Fingerprint

Circoviridae
Beak and feather disease virus
Circovirus
phylogeny
viruses
ssDNA viruses
Psittaciformes
vertebrate viruses
genome
birds
waterfowl
population genetics
ancestry
niches

Grant Number

  • FT120100242

Cite this

Das, S., Sarker, S., Peters, A., Ghorashi, S., Phalen, D., Forwood, J., & Raidal, S. (2016). Circoviruses evolve more slowly than their hosts. Abstract from Australian Society for Microbiology Annual Scientific Meeting and Exhibition (ASM 2016), Australia.
Das, Shubhagata ; Sarker, Subir ; Peters, Andrew ; Ghorashi, Seyed ; Phalen, David ; Forwood, Jade ; Raidal, Shane. / Circoviruses evolve more slowly than their hosts. Abstract from Australian Society for Microbiology Annual Scientific Meeting and Exhibition (ASM 2016), Australia.1 p.
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author = "Shubhagata Das and Subir Sarker and Andrew Peters and Seyed Ghorashi and David Phalen and Jade Forwood and Shane Raidal",
note = "Imported on 03 May 2017 - DigiTool details were: publisher = 2016. Event dates (773o) = 3-6 July 2016; Parent title (773t) = Australian Society for Microbiology Annual Scientific Meeting and Exhibition (ASM 2016).; Australian Society for Microbiology Annual Scientific Meeting and Exhibition (ASM 2016) ; Conference date: 03-07-2016 Through 06-07-2016",
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Das, S, Sarker, S, Peters, A, Ghorashi, S, Phalen, D, Forwood, J & Raidal, S 2016, 'Circoviruses evolve more slowly than their hosts' Australian Society for Microbiology Annual Scientific Meeting and Exhibition (ASM 2016), Australia, 03/07/16 - 06/07/16, .

Circoviruses evolve more slowly than their hosts. / Das, Shubhagata; Sarker, Subir; Peters, Andrew; Ghorashi, Seyed; Phalen, David; Forwood, Jade; Raidal, Shane.

2016. Abstract from Australian Society for Microbiology Annual Scientific Meeting and Exhibition (ASM 2016), Australia.

Research output: Other contribution to conferenceAbstract

TY - CONF

T1 - Circoviruses evolve more slowly than their hosts

AU - Das, Shubhagata

AU - Sarker, Subir

AU - Peters, Andrew

AU - Ghorashi, Seyed

AU - Phalen, David

AU - Forwood, Jade

AU - Raidal, Shane

N1 - Imported on 03 May 2017 - DigiTool details were: publisher = 2016. Event dates (773o) = 3-6 July 2016; Parent title (773t) = Australian Society for Microbiology Annual Scientific Meeting and Exhibition (ASM 2016).

PY - 2016

Y1 - 2016

N2 - Emerging evidence of endogenous viral elements in host genomes hints towards much older host-virus relationships than predicted by exogenous phylogenies. Resolving the long-term evolutionary history of vertebrate virus-host association and determining the age of a potentially ancient tree based only fresh shoots at the tips is problematic, especially when purifying selection or recombination significantly alters the accuracy of phylogenetic reconstruction methods. Pathogens which occupy entangled multispecies ecological niches add a further layer of complexity but these multi-host scenarios may also provide opportunities to identify allopatric orsympatric paleobiological signals that can unlock longer term phylogenies. Circoviruses are highly mutable single-stranded DNA (ssDNA) viruses with a high rate of genetic admixture through recombination, particularly in beak and feather disease virus (BFDV) which provides an excellent model for studying multi-host scenarios with host-switching events. We generated whole genome circoviral sequences from Australian psittacine birds and analysed those using phylogenetic reconstruction and population genetics approach to infer the macroevolutionary scenario. Endogenous circoviral motifs in kea (Nestor notabilis) with Gondwanan vicariance estimates were used to calibrate the evolutionary timescale. We identified host-based, cryptic, sympatric differentiation in BFDV in the Psittaciforme tribe Loriini with 10 million year divergence coinciding with the Papuan central range orogeny that triggered the radiation of Loriini and segregation of an antecedent viral clade in Australian lorikeets. We also demonstrated a chronology of circovirus speciation in birds highlighting a Gondwanan dominant group in Neoaves with passerine, columbid and larid circoviruses deeply separated from those in waterfowl, consistent with a Triassic divergence of Galloanserae. The circovirus tree had a deep ancestry in invertebrates with a Palaeozoic expansion in fish and mammals. We show how a virus that mutates rapidly might also retain phenotypic stability and wait millennia to change hosts or become a recognisable new virus species, a process that could lag well behind the evolution of the potential hosts.

AB - Emerging evidence of endogenous viral elements in host genomes hints towards much older host-virus relationships than predicted by exogenous phylogenies. Resolving the long-term evolutionary history of vertebrate virus-host association and determining the age of a potentially ancient tree based only fresh shoots at the tips is problematic, especially when purifying selection or recombination significantly alters the accuracy of phylogenetic reconstruction methods. Pathogens which occupy entangled multispecies ecological niches add a further layer of complexity but these multi-host scenarios may also provide opportunities to identify allopatric orsympatric paleobiological signals that can unlock longer term phylogenies. Circoviruses are highly mutable single-stranded DNA (ssDNA) viruses with a high rate of genetic admixture through recombination, particularly in beak and feather disease virus (BFDV) which provides an excellent model for studying multi-host scenarios with host-switching events. We generated whole genome circoviral sequences from Australian psittacine birds and analysed those using phylogenetic reconstruction and population genetics approach to infer the macroevolutionary scenario. Endogenous circoviral motifs in kea (Nestor notabilis) with Gondwanan vicariance estimates were used to calibrate the evolutionary timescale. We identified host-based, cryptic, sympatric differentiation in BFDV in the Psittaciforme tribe Loriini with 10 million year divergence coinciding with the Papuan central range orogeny that triggered the radiation of Loriini and segregation of an antecedent viral clade in Australian lorikeets. We also demonstrated a chronology of circovirus speciation in birds highlighting a Gondwanan dominant group in Neoaves with passerine, columbid and larid circoviruses deeply separated from those in waterfowl, consistent with a Triassic divergence of Galloanserae. The circovirus tree had a deep ancestry in invertebrates with a Palaeozoic expansion in fish and mammals. We show how a virus that mutates rapidly might also retain phenotypic stability and wait millennia to change hosts or become a recognisable new virus species, a process that could lag well behind the evolution of the potential hosts.

M3 - Abstract

ER -

Das S, Sarker S, Peters A, Ghorashi S, Phalen D, Forwood J et al. Circoviruses evolve more slowly than their hosts. 2016. Abstract from Australian Society for Microbiology Annual Scientific Meeting and Exhibition (ASM 2016), Australia.