TY - JOUR
T1 - Circulating inflammatory markers and hemostatic factors in age-related maculopathy
T2 - a population-based case-control study
AU - Wu, Kathy H C
AU - Tan, Ava Grace
AU - Rochtchina, Elena
AU - Favaloro, Emmanuel J
AU - Williams, Andrew
AU - Mitchell, Paul
AU - Wang, Jie Jin
PY - 2007/5
Y1 - 2007/5
N2 - PURPOSE: To examine the relationship between circulating inflammatory markers, hemostatic factors, and age-related maculopathy (ARM).METHODS: A population-based, cross-sectional case-control study drawn from the Blue Mountains Eye Study included 159 early and 38 late ARM cases, and 433 controls matched for age, gender, and smoking. ARM lesions were assessed from retinal photographs according to the Wisconsin ARM grading system. Circulating inflammatory markers (high-sensitivity C-reactive protein [hsCRP], intercellular adhesion molecule [ICAM]-1, and interleukin [IL]-6), white cell count (WCC), and hemostatic factors (fibrinogen, homocysteine, plasminogen activator inhibitor [PAI]-1 and von Willebrand factor [vWF]) were assessed. Age, gender, current smoking, body mass index, hypertension, history of stroke, and cardiovascular events were adjusted for. Adjusted mean levels of each marker were compared between persons with early ARM, those with late ARM, and control subjects, and are presented as probabilities. Adjusted associations with ARM were examined continuously (per SD), and are presented as odds ratios (ORs) and 95% confidence intervals (CIs). Summarizing z scores for inflammation and hemostatic dysfunction were calculated.RESULTS: Increased PAI-1 level was associated with both early (OR 1.2, 95% CI 1.0-1.4 per SD increase) and late ARM (OR 1.3, 95% CI 0.9-1.9 per SD increase). Elevated ICAM-1 level was marginally associated with late ARM (OR 1.3, 95% CI 1.0-1.7 per SD increase). No other significant associations were found between the remaining inflammatory or hemostatic markers and either early or late ARM. Summarized z scores for inflammatory or hemostatic markers also did not suggest any associations.CONCLUSIONS: There was no consistent pattern of association found between ARM and circulating inflammatory markers or hemostatic factors in this population-based case-control study.
AB - PURPOSE: To examine the relationship between circulating inflammatory markers, hemostatic factors, and age-related maculopathy (ARM).METHODS: A population-based, cross-sectional case-control study drawn from the Blue Mountains Eye Study included 159 early and 38 late ARM cases, and 433 controls matched for age, gender, and smoking. ARM lesions were assessed from retinal photographs according to the Wisconsin ARM grading system. Circulating inflammatory markers (high-sensitivity C-reactive protein [hsCRP], intercellular adhesion molecule [ICAM]-1, and interleukin [IL]-6), white cell count (WCC), and hemostatic factors (fibrinogen, homocysteine, plasminogen activator inhibitor [PAI]-1 and von Willebrand factor [vWF]) were assessed. Age, gender, current smoking, body mass index, hypertension, history of stroke, and cardiovascular events were adjusted for. Adjusted mean levels of each marker were compared between persons with early ARM, those with late ARM, and control subjects, and are presented as probabilities. Adjusted associations with ARM were examined continuously (per SD), and are presented as odds ratios (ORs) and 95% confidence intervals (CIs). Summarizing z scores for inflammation and hemostatic dysfunction were calculated.RESULTS: Increased PAI-1 level was associated with both early (OR 1.2, 95% CI 1.0-1.4 per SD increase) and late ARM (OR 1.3, 95% CI 0.9-1.9 per SD increase). Elevated ICAM-1 level was marginally associated with late ARM (OR 1.3, 95% CI 1.0-1.7 per SD increase). No other significant associations were found between the remaining inflammatory or hemostatic markers and either early or late ARM. Summarized z scores for inflammatory or hemostatic markers also did not suggest any associations.CONCLUSIONS: There was no consistent pattern of association found between ARM and circulating inflammatory markers or hemostatic factors in this population-based case-control study.
KW - Aged
KW - Aged, 80 and over
KW - Blood Coagulation Factors/metabolism
KW - C-Reactive Protein/metabolism
KW - Case-Control Studies
KW - Cross-Sectional Studies
KW - Female
KW - Homocysteine/blood
KW - Humans
KW - Intercellular Adhesion Molecule-1/blood
KW - Interleukin-6/blood
KW - Leukocyte Count
KW - Macular Degeneration/blood
KW - Male
KW - Middle Aged
KW - Risk Factors
U2 - 10.1167/iovs.06-0223
DO - 10.1167/iovs.06-0223
M3 - Article
C2 - 17460250
SN - 0146-0404
VL - 48
SP - 1983
EP - 1988
JO - Investigative Ophthalmology & Visual Science
JF - Investigative Ophthalmology & Visual Science
IS - 5
ER -