Clinical and genetic associations of renal function and diabetic kidney disease in the United Arab Emirates: A cross-sectional study

Wael M. Osman, Herbert F. Jelinek, Guan K. Tay, Ahsan H. Khandoker, Kinda Khalaf, Wael Almahmeed, Mohamed H. Hassan, Habiba S. Alsafar

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Abstract

Within the Emirati population, risk factors and genetic predisposition to diabetic kidney disease (DKD) have not yet been investigated The aim of this research was to determine potential clinical, laboratory and reported genetic loci as risk factors for DKD Research design and methods Four hundred and ninety unrelated Emirati nationals with type 2 diabetes mellitus (T2DM) were recruited with and without DKD, and clinical and laboratory data were obtained Following adjustments for possible confounders, a logistic regression model was developed to test the associations of 63 single nucleotide polymorphisms (SNPs) in 43 genetic loci with DKD (145 patients with DKD and 265 without DKD) Linear regression models, adjusted for age and gender, were then used to study the genetic associations of five renal function traits, including 83 SNPs with albumin-to-creatinine ratio, 92 SNPs with vitamin D (25-OH cholecalciferol), 288 SNPs with estimated glomerular filtration rate (eGFR), 363 SNPs with serum creatinine and 73 SNPs with blood urea Results Patients with DKD, as compared with those without the disease, were mostly men (52%vs38% for controls), older (67vs59 years) and had significant rates of hypertension and dyslipidaemia Furthermore, patients with DKD had T2DM for a longer duration of time (16vs10 years), which in an additive manner was the single factor that significantly contributed to the development of DKD (p=002, OR=312, 95% CI 121 to 802) Among the replicated associations of the genetic loci with different renal function traits, the most notable included SHROOM3 with levels of serum creatinine, eGFR and DKD (P adjusted =004, OR=146); CASR, GC and CYP2R1 with vitamin D levels; as well as WDR72 with serum creatinine and eGFR levels Conclusions Associations were found between several genetic loci and risk markers for DKD, which may influence kidney function traits and DKD in a population of Arab ancestry.
Original languageEnglish
Article numbere020759
Pages (from-to)1-9
Number of pages9
JournalBMJ Open
Volume8
Issue number12
DOIs
Publication statusPublished - 14 Dec 2018

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United Arab Emirates
Diabetic Nephropathies
Cross-Sectional Studies
Kidney
Single Nucleotide Polymorphism
Genetic Loci
Creatinine
Glomerular Filtration Rate
Vitamin D
Type 2 Diabetes Mellitus
Linear Models
Logistic Models
Serum
Cholecalciferol
Genetic Association Studies
Genetic Predisposition to Disease
Dyslipidemias
Population
Urea
Albumins

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Osman, Wael M. ; Jelinek, Herbert F. ; Tay, Guan K. ; Khandoker, Ahsan H. ; Khalaf, Kinda ; Almahmeed, Wael ; Hassan, Mohamed H. ; Alsafar, Habiba S. / Clinical and genetic associations of renal function and diabetic kidney disease in the United Arab Emirates : A cross-sectional study. In: BMJ Open. 2018 ; Vol. 8, No. 12. pp. 1-9.
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abstract = "Within the Emirati population, risk factors and genetic predisposition to diabetic kidney disease (DKD) have not yet been investigated The aim of this research was to determine potential clinical, laboratory and reported genetic loci as risk factors for DKD Research design and methods Four hundred and ninety unrelated Emirati nationals with type 2 diabetes mellitus (T2DM) were recruited with and without DKD, and clinical and laboratory data were obtained Following adjustments for possible confounders, a logistic regression model was developed to test the associations of 63 single nucleotide polymorphisms (SNPs) in 43 genetic loci with DKD (145 patients with DKD and 265 without DKD) Linear regression models, adjusted for age and gender, were then used to study the genetic associations of five renal function traits, including 83 SNPs with albumin-to-creatinine ratio, 92 SNPs with vitamin D (25-OH cholecalciferol), 288 SNPs with estimated glomerular filtration rate (eGFR), 363 SNPs with serum creatinine and 73 SNPs with blood urea Results Patients with DKD, as compared with those without the disease, were mostly men (52{\%}vs38{\%} for controls), older (67vs59 years) and had significant rates of hypertension and dyslipidaemia Furthermore, patients with DKD had T2DM for a longer duration of time (16vs10 years), which in an additive manner was the single factor that significantly contributed to the development of DKD (p=002, OR=312, 95{\%} CI 121 to 802) Among the replicated associations of the genetic loci with different renal function traits, the most notable included SHROOM3 with levels of serum creatinine, eGFR and DKD (P adjusted =004, OR=146); CASR, GC and CYP2R1 with vitamin D levels; as well as WDR72 with serum creatinine and eGFR levels Conclusions Associations were found between several genetic loci and risk markers for DKD, which may influence kidney function traits and DKD in a population of Arab ancestry.",
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Osman, WM, Jelinek, HF, Tay, GK, Khandoker, AH, Khalaf, K, Almahmeed, W, Hassan, MH & Alsafar, HS 2018, 'Clinical and genetic associations of renal function and diabetic kidney disease in the United Arab Emirates: A cross-sectional study', BMJ Open, vol. 8, no. 12, e020759, pp. 1-9. https://doi.org/10.1136/bmjopen-2017-020759

Clinical and genetic associations of renal function and diabetic kidney disease in the United Arab Emirates : A cross-sectional study. / Osman, Wael M.; Jelinek, Herbert F.; Tay, Guan K.; Khandoker, Ahsan H.; Khalaf, Kinda; Almahmeed, Wael; Hassan, Mohamed H.; Alsafar, Habiba S.

In: BMJ Open, Vol. 8, No. 12, e020759, 14.12.2018, p. 1-9.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical and genetic associations of renal function and diabetic kidney disease in the United Arab Emirates

T2 - A cross-sectional study

AU - Osman, Wael M.

AU - Jelinek, Herbert F.

AU - Tay, Guan K.

AU - Khandoker, Ahsan H.

AU - Khalaf, Kinda

AU - Almahmeed, Wael

AU - Hassan, Mohamed H.

AU - Alsafar, Habiba S.

PY - 2018/12/14

Y1 - 2018/12/14

N2 - Within the Emirati population, risk factors and genetic predisposition to diabetic kidney disease (DKD) have not yet been investigated The aim of this research was to determine potential clinical, laboratory and reported genetic loci as risk factors for DKD Research design and methods Four hundred and ninety unrelated Emirati nationals with type 2 diabetes mellitus (T2DM) were recruited with and without DKD, and clinical and laboratory data were obtained Following adjustments for possible confounders, a logistic regression model was developed to test the associations of 63 single nucleotide polymorphisms (SNPs) in 43 genetic loci with DKD (145 patients with DKD and 265 without DKD) Linear regression models, adjusted for age and gender, were then used to study the genetic associations of five renal function traits, including 83 SNPs with albumin-to-creatinine ratio, 92 SNPs with vitamin D (25-OH cholecalciferol), 288 SNPs with estimated glomerular filtration rate (eGFR), 363 SNPs with serum creatinine and 73 SNPs with blood urea Results Patients with DKD, as compared with those without the disease, were mostly men (52%vs38% for controls), older (67vs59 years) and had significant rates of hypertension and dyslipidaemia Furthermore, patients with DKD had T2DM for a longer duration of time (16vs10 years), which in an additive manner was the single factor that significantly contributed to the development of DKD (p=002, OR=312, 95% CI 121 to 802) Among the replicated associations of the genetic loci with different renal function traits, the most notable included SHROOM3 with levels of serum creatinine, eGFR and DKD (P adjusted =004, OR=146); CASR, GC and CYP2R1 with vitamin D levels; as well as WDR72 with serum creatinine and eGFR levels Conclusions Associations were found between several genetic loci and risk markers for DKD, which may influence kidney function traits and DKD in a population of Arab ancestry.

AB - Within the Emirati population, risk factors and genetic predisposition to diabetic kidney disease (DKD) have not yet been investigated The aim of this research was to determine potential clinical, laboratory and reported genetic loci as risk factors for DKD Research design and methods Four hundred and ninety unrelated Emirati nationals with type 2 diabetes mellitus (T2DM) were recruited with and without DKD, and clinical and laboratory data were obtained Following adjustments for possible confounders, a logistic regression model was developed to test the associations of 63 single nucleotide polymorphisms (SNPs) in 43 genetic loci with DKD (145 patients with DKD and 265 without DKD) Linear regression models, adjusted for age and gender, were then used to study the genetic associations of five renal function traits, including 83 SNPs with albumin-to-creatinine ratio, 92 SNPs with vitamin D (25-OH cholecalciferol), 288 SNPs with estimated glomerular filtration rate (eGFR), 363 SNPs with serum creatinine and 73 SNPs with blood urea Results Patients with DKD, as compared with those without the disease, were mostly men (52%vs38% for controls), older (67vs59 years) and had significant rates of hypertension and dyslipidaemia Furthermore, patients with DKD had T2DM for a longer duration of time (16vs10 years), which in an additive manner was the single factor that significantly contributed to the development of DKD (p=002, OR=312, 95% CI 121 to 802) Among the replicated associations of the genetic loci with different renal function traits, the most notable included SHROOM3 with levels of serum creatinine, eGFR and DKD (P adjusted =004, OR=146); CASR, GC and CYP2R1 with vitamin D levels; as well as WDR72 with serum creatinine and eGFR levels Conclusions Associations were found between several genetic loci and risk markers for DKD, which may influence kidney function traits and DKD in a population of Arab ancestry.

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KW - Diabetes

KW - Renal

KW - Uae

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