Clinical and pathologic relevance of p53 index in canine osseous tumors

Panayiotis Loukopoulos, John R. Thornton , Wayne F. Robinson

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The clinicopathologic value of the immunohistochemical (IHC) expression of p53 protein was evaluated in 167 canine osseous tumors. p53 staining frequency and intensity in tumor cells was expressed as a p53 index. p53 index was significantly higher in osteosarcomas than in other sarcomas, chondrosarcoma, multilobular tumor of bone, and tumors initially misdiagnosed as osteosarcomas as well as in appendicular versus axial and in distal versus proximal osteosarcomas. A strong correlation is demonstrated between the p53 index and a range of clinicopathologic parameters in osteosarcoma, including the tumor site, histologic grade and score, mitotic index, degree of tumor necrosis, and pleomorphism. Chondroblastic osteosarcomas had significantly higher and telangiectatic osteosarcomas significantly lower p53 index than did osteosarcomas belonging to other histopathologic subtypes, a fact that tends to reinforce the perception of these osteosarcomas as distinct clinicopathologic entities. Entire males had higher p53 index than did neutered males. p53 index was higher in Rottweilers than in Great Danes and Terriers, confirming breed susceptibilities to osteosarcoma. p53 index showed no association with age, primary or secondary site status, or the presence of metastases or other tumor types. Biopsy samples had a higher p53 index than did postmortem samples, either because of differences in sample processing or the possibility that p53 overexpression is more evident at the earlier stages of osteosarcoma pathogenesis, presumably represented by the biopsy material. IHC examination for p53 and the derived index has the potential to be used as an additional diagnostic tool and prognostic indicator for osseous tumors.
Original languageEnglish
Article number12724563
Pages (from-to)237-48
Number of pages12
JournalVeterinary Pathology
Volume40
Issue number3
Publication statusPublished - 2003

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  • Prizes

    Australian Companion Animal Health Foundation Research Grant

    Panos Loukopoulos (Recipient), Rodney C. Straw (Recipient), John R. Thornton (Recipient) & Wayne F. Robinson (Recipient), 1999

    Prize: Award

  • Australian Companion Animal Health Foundation Research Grant

    Panos Loukopoulos (Recipient), Wayne F. Robinson (Recipient), John R. Thornton (Recipient) & Rodney C. Straw (Recipient), 1998

    Prize: Award

  • Bequest of Brown Emily Perrett “for the benefit of animal health and welfare, including diagnosis and treatment of cancer in cats and dogs.”

    Panos Loukopoulos (Recipient), Wayne F. Robinson (Recipient) & John R. Thornton (Recipient), 1997

    Prize: Award

  • Activities

    • 1 Public lecture/debate/seminar/presentation

    Combined Veterinary Pathology and Anatomy and Companion Animal Sciences Seminar, School of Veterinary Science, University of Queensland

    Panos Loukopoulos (Speaker)

    Aug 1998

    Activity: Participating in or organising an eventPublic lecture/debate/seminar/presentationIndustry

    Cite this

    Loukopoulos, P., Thornton , J. R., & Robinson, W. F. (2003). Clinical and pathologic relevance of p53 index in canine osseous tumors. Veterinary Pathology, 40(3), 237-48. [12724563].