Clomethiazole: mechanisms underlying lasting neuroprotection following hypoxia-ischemia

Andrew N. Clarkson, Hanzhong Liu, Rosanna Rahman, David Jackson, Ian Appleton, D. Steven Kerr

Research output: Contribution to journalArticle

40 Citations (Scopus)


Clomethiazole (CMZ) a GABAA receptor agonist has been shown to be neuroprotective in models of both focal and global ischemia. In the present study we used a modified 'Levine' rat-pup model (unilateral carotid arteryligation, coupled with global hypoxia), to evaluate the lasting (90 days) effects of CMZ on HI-induced neuronal damage. We also assessed neuronal activity from hippocampal region CA1 and the activity of key inflammatory mediators, namely nitric oxide synthase (NOS) and arginase, ipsilateral and contralateral to the occlusion.
Original languageEnglish
Pages (from-to)1036-1038
Number of pages3
JournalFASEB Journal
Issue number8
Publication statusPublished - 2005

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