Coloured rice-derived polyphenols reduce lipid peroxidation and pro-inflammatory cytokines ex vivo

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Rice-derived polyphenols have been demonstrated to alleviate obesity-related oxidative stress and inflammation. The aim of the study was to investigate if coloured rice polyphenol extracts (PE) reduce malondialdehyde, interleukin-6 and tumour necrosis factor-α (TNF-α) levels in obese individuals ex vivo. Malondialdehyde and pro-inflammatory cytokines were quantified using high-performance liquid chromatography and flow cytometry respectively. Fasting blood samples were treated with PE from three coloured rice varieties (purple, red and brown rice) at varying concentrations (10, 20, 50, 100, 200 and 500 μg mL−1). PE treatment demonstrated a dose-dependent reduction in malondialdehyde and TNF-α levels. Purple PE reduced plasma malondialdehyde concentration by 59% compared to red (21%) and brown (25.5%) rice PE. Brown rice PE at 50 μg mL−1 reduced TNF-α levels by 98% compared to red (80%) and purple rice PE (74%). Rice PE did not modulate plasma interleukin-6 concentrations. Coloured rice may be of therapeutic benefit as a potential functional food alternative in targeting specific pathways associated with obesity.
Original languageEnglish
Pages (from-to)5169-5175
Number of pages7
JournalFood and Function
Volume9
Issue number10
Early online date20 Sep 2018
DOIs
Publication statusPublished - 01 Oct 2018

Fingerprint

Polyphenols
Lipid Peroxidation
polyphenols
lipid peroxidation
cytokines
Cytokines
rice
extracts
Malondialdehyde
malondialdehyde
brown rice
tumor necrosis factors
Tumor Necrosis Factor-alpha
interleukin-6
Interleukin-6
obesity
Obesity
red rice
Oryza
Functional Food

Cite this

@article{3bfb8ad2e3f24f0ea36c96361c4f35c6,
title = "Coloured rice-derived polyphenols reduce lipid peroxidation and pro-inflammatory cytokines ex vivo",
abstract = "Rice-derived polyphenols have been demonstrated to alleviate obesity-related oxidative stress and inflammation. The aim of the study was to investigate if coloured rice polyphenol extracts (PE) reduce malondialdehyde, interleukin-6 and tumour necrosis factor-α (TNF-α) levels in obese individuals ex vivo. Malondialdehyde and pro-inflammatory cytokines were quantified using high-performance liquid chromatography and flow cytometry respectively. Fasting blood samples were treated with PE from three coloured rice varieties (purple, red and brown rice) at varying concentrations (10, 20, 50, 100, 200 and 500 μg mL−1). PE treatment demonstrated a dose-dependent reduction in malondialdehyde and TNF-α levels. Purple PE reduced plasma malondialdehyde concentration by 59{\%} compared to red (21{\%}) and brown (25.5{\%}) rice PE. Brown rice PE at 50 μg mL−1 reduced TNF-α levels by 98{\%} compared to red (80{\%}) and purple rice PE (74{\%}). Rice PE did not modulate plasma interleukin-6 concentrations. Coloured rice may be of therapeutic benefit as a potential functional food alternative in targeting specific pathways associated with obesity.",
author = "Esther Callcott and Kiara Thompson and Prakash Oli and Christopher Blanchard and Abishek Santhakumar",
year = "2018",
month = "10",
day = "1",
doi = "10.1039/c8fo01531g",
language = "English",
volume = "9",
pages = "5169--5175",
journal = "Food and Function",
issn = "2042-6496",
publisher = "Royal Society of Chemistry",
number = "10",

}

Coloured rice-derived polyphenols reduce lipid peroxidation and pro-inflammatory cytokines ex vivo. / Callcott, Esther; Thompson, Kiara; Oli, Prakash; Blanchard, Christopher; Santhakumar, Abishek.

In: Food and Function, Vol. 9, No. 10, 01.10.2018, p. 5169-5175.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Coloured rice-derived polyphenols reduce lipid peroxidation and pro-inflammatory cytokines ex vivo

AU - Callcott, Esther

AU - Thompson, Kiara

AU - Oli, Prakash

AU - Blanchard, Christopher

AU - Santhakumar, Abishek

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Rice-derived polyphenols have been demonstrated to alleviate obesity-related oxidative stress and inflammation. The aim of the study was to investigate if coloured rice polyphenol extracts (PE) reduce malondialdehyde, interleukin-6 and tumour necrosis factor-α (TNF-α) levels in obese individuals ex vivo. Malondialdehyde and pro-inflammatory cytokines were quantified using high-performance liquid chromatography and flow cytometry respectively. Fasting blood samples were treated with PE from three coloured rice varieties (purple, red and brown rice) at varying concentrations (10, 20, 50, 100, 200 and 500 μg mL−1). PE treatment demonstrated a dose-dependent reduction in malondialdehyde and TNF-α levels. Purple PE reduced plasma malondialdehyde concentration by 59% compared to red (21%) and brown (25.5%) rice PE. Brown rice PE at 50 μg mL−1 reduced TNF-α levels by 98% compared to red (80%) and purple rice PE (74%). Rice PE did not modulate plasma interleukin-6 concentrations. Coloured rice may be of therapeutic benefit as a potential functional food alternative in targeting specific pathways associated with obesity.

AB - Rice-derived polyphenols have been demonstrated to alleviate obesity-related oxidative stress and inflammation. The aim of the study was to investigate if coloured rice polyphenol extracts (PE) reduce malondialdehyde, interleukin-6 and tumour necrosis factor-α (TNF-α) levels in obese individuals ex vivo. Malondialdehyde and pro-inflammatory cytokines were quantified using high-performance liquid chromatography and flow cytometry respectively. Fasting blood samples were treated with PE from three coloured rice varieties (purple, red and brown rice) at varying concentrations (10, 20, 50, 100, 200 and 500 μg mL−1). PE treatment demonstrated a dose-dependent reduction in malondialdehyde and TNF-α levels. Purple PE reduced plasma malondialdehyde concentration by 59% compared to red (21%) and brown (25.5%) rice PE. Brown rice PE at 50 μg mL−1 reduced TNF-α levels by 98% compared to red (80%) and purple rice PE (74%). Rice PE did not modulate plasma interleukin-6 concentrations. Coloured rice may be of therapeutic benefit as a potential functional food alternative in targeting specific pathways associated with obesity.

UR - http://www.scopus.com/inward/record.url?scp=85055077321&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85055077321&partnerID=8YFLogxK

U2 - 10.1039/c8fo01531g

DO - 10.1039/c8fo01531g

M3 - Article

VL - 9

SP - 5169

EP - 5175

JO - Food and Function

JF - Food and Function

SN - 2042-6496

IS - 10

ER -