This report documents the treatment of a case of chronic pleuropneumonia in a 3-year-old Thoroughbred gelding. A recombinant tissue plasminogen activator (tenecteplase) and a recombinant deoxyribonucleic acidase (alphadornase) were infused into the pleural cavity as adjunctive therapy in the early stages of treatment. Instillation of fibrinolytic drugs was associated with a subjective reduction in the amount of fibrin deposition and decreased fluid accumulation within the pleural cavities. Fibrinolytic therapy may be a useful adjunctive therapy in selected cases of intrapleural disease in horses.
Rendle, D., Armstrong, S., & Hughes, K. (2012). Combination fibrinolytic therapy in the treatment of chronic septic pleuropneumonia in a Thoroughbred gelding. Australian Veterinary Journal, 90(9), 358-362. https://doi.org/10.1111/j.1751-0813.2012.00962.x