Comparative Pathology of Pulmonary Hydatid Cysts in Macropods and Sheep

T. S. Barnes, L. A. Hinds, David Jenkins, H. Bielefeldt-Ohmann, M. W. Lightowlers, G. T. Coleman

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The development and appearance of hydatid cysts of Echinococcus granulosus in experimentally infected tammar wallabies (Macropus eugenii) and sheep during the period 9e17 months post-infection (mpi) were studied. Cystsof unknown age were also examined from mature, naturally infected sheep. The cysts grew more rapidly and became fertile within a shorter period in wallabies compared with sheep. Cysts from the wallabies were larger in absolute size and were larger relative to the size of the lungs. Microscopical examination revealed that wallaby hydatid cysts developed in small bronchioles. Hydatid cysts in the wallabies had a thicker germinal membrane,with more nuclei and a thicker laminated layer (LL), than hydatid cysts of similar age found in sheep. In contrast, the adventitial layer was thicker in the ovine cysts, comprising a hyalinized layer of degenerate collagen and necrotic cellular debris surrounded by a layer of granulation tissue that was largely absent from lesions in the wallabies. Multilocular cysts were present in sheep, but not in wallabies. The greater thickness of the germinal membrane in wallaby cysts suggests greater parasite activity, which may explain the more rapid growth rate in this host, whereas the thicker adventitial layer in sheep cysts may be restrictive to growth while simultaneously protecting the hydatid from the host immune response. These differences in the parasite ehostrelationship between macropods and sheep may reflect the relatively recent introduction of the parasite into Australia
Original languageEnglish
Pages (from-to)113-122
Number of pages10
JournalJournal of Comparative Pathology
Volume144
Issue number2-3
Early online date2010
DOIs
Publication statusPublished - 2011

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