Complex correlation measure as a sensitive indicator of risk for sudden cardiac death in patients with depression

Herbert Jelinek, Ahsan H. Khandoker, D.S. Quintana, Md Hasan Imam, A.H. Kemp

Research output: Book chapter/Published conference paperConference paperpeer-review

10 Citations (Scopus)
40 Downloads (Pure)

Abstract

Heart rate variability (HRV) is reduced in patients with Major Depressive Disorder (MDD). We examined the sensitivity of a new nonlinear parameter, the Complex Correlation Measure (CCM) in patients with depression. Two-minute ECG recordings at rest with eyes-closed were analysed. CCM was higher (0.36±0.1) in control participants compared to MDD (0.29±0.1), indicating a decrease in temporal variability associated with decreased parasympathetic function (Cohen's d = 0.7,p=0.0008). CCM also demonstrated a larger effect size than SD1 (Cohen's d = 0.5, p =0.0005) and SD2 (Cohen's d = 0.2, p = 0.015). These results highlight that depressed patients display a dampening of oscillations between parasympathetic and sympathetic input indicative of reduced functionality and increased risk of sudden cardiac death. CCM is a more sensitive measure of HRV, which provides additional information on HRV dynamics compared to SD1 and SD2 of the Poincaré plot distribution.
Original languageEnglish
Title of host publicationCinC 2011
Place of PublicationMissouri, US
PublisherComputers in Cardiology
Pages809-812
Number of pages4
Volume38
Publication statusPublished - 2011
EventComputers in Cardiology - Hangzhou, China, China
Duration: 18 Sep 201121 Sep 2011

Publication series

Name
ISSN (Print)0276-6574

Conference

ConferenceComputers in Cardiology
CountryChina
Period18/09/1121/09/11

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