TY - GEN
T1 - Complex correlation measure as a sensitive indicator of risk for sudden cardiac death in patients with depression
AU - Jelinek, Herbert
AU - Khandoker, Ahsan H.
AU - Quintana, D.S.
AU - Imam, Md Hasan
AU - Kemp, A.H.
N1 - Imported on 03 May 2017 - DigiTool details were: publisher = Missouri, US: Computers in Cardiology, 2011. Event dates (773o) = 18-21 September,2011; Parent title (773t) = Computers in Cardiology. ISSNs: 0276-6574;
PY - 2011
Y1 - 2011
N2 - Heart rate variability (HRV) is reduced in patients with Major Depressive Disorder (MDD). We examined the sensitivity of a new nonlinear parameter, the Complex Correlation Measure (CCM) in patients with depression. Two-minute ECG recordings at rest with eyes-closed were analysed. CCM was higher (0.36±0.1) in control participants compared to MDD (0.29±0.1), indicating a decrease in temporal variability associated with decreased parasympathetic function (Cohen's d = 0.7,p=0.0008). CCM also demonstrated a larger effect size than SD1 (Cohen's d = 0.5, p =0.0005) and SD2 (Cohen's d = 0.2, p = 0.015). These results highlight that depressed patients display a dampening of oscillations between parasympathetic and sympathetic input indicative of reduced functionality and increased risk of sudden cardiac death. CCM is a more sensitive measure of HRV, which provides additional information on HRV dynamics compared to SD1 and SD2 of the Poincaré plot distribution.
AB - Heart rate variability (HRV) is reduced in patients with Major Depressive Disorder (MDD). We examined the sensitivity of a new nonlinear parameter, the Complex Correlation Measure (CCM) in patients with depression. Two-minute ECG recordings at rest with eyes-closed were analysed. CCM was higher (0.36±0.1) in control participants compared to MDD (0.29±0.1), indicating a decrease in temporal variability associated with decreased parasympathetic function (Cohen's d = 0.7,p=0.0008). CCM also demonstrated a larger effect size than SD1 (Cohen's d = 0.5, p =0.0005) and SD2 (Cohen's d = 0.2, p = 0.015). These results highlight that depressed patients display a dampening of oscillations between parasympathetic and sympathetic input indicative of reduced functionality and increased risk of sudden cardiac death. CCM is a more sensitive measure of HRV, which provides additional information on HRV dynamics compared to SD1 and SD2 of the Poincaré plot distribution.
KW - Open access version available
M3 - Conference paper
VL - 38
SP - 809
EP - 812
BT - CinC 2011
PB - Computers in Cardiology
CY - Missouri, US
T2 - Computers in Cardiology
Y2 - 18 September 2011 through 21 September 2011
ER -