@inproceedings{297698fe78c34751a94700a61dfe2c14,
title = "Complex correlation measure as a sensitive indicator of risk for sudden cardiac death in patients with depression",
abstract = "Heart rate variability (HRV) is reduced in patients with Major Depressive Disorder (MDD). We examined the sensitivity of a new nonlinear parameter, the Complex Correlation Measure (CCM) in patients with depression. Two-minute ECG recordings at rest with eyes-closed were analysed. CCM was higher (0.36±0.1) in control participants compared to MDD (0.29±0.1), indicating a decrease in temporal variability associated with decreased parasympathetic function (Cohen's d = 0.7,p=0.0008). CCM also demonstrated a larger effect size than SD1 (Cohen's d = 0.5, p =0.0005) and SD2 (Cohen's d = 0.2, p = 0.015). These results highlight that depressed patients display a dampening of oscillations between parasympathetic and sympathetic input indicative of reduced functionality and increased risk of sudden cardiac death. CCM is a more sensitive measure of HRV, which provides additional information on HRV dynamics compared to SD1 and SD2 of the Poincar{\'e} plot distribution.",
keywords = "Open access version available",
author = "Herbert Jelinek and Khandoker, {Ahsan H.} and D.S. Quintana and Imam, {Md Hasan} and A.H. Kemp",
year = "2011",
language = "English",
volume = "38",
publisher = "Computers in Cardiology",
pages = "809--812",
booktitle = "CinC 2011",
note = "Computers in Cardiology ; Conference date: 18-09-2011 Through 21-09-2011",
}