Complexity of heart rate variability in type 2 diabetes: Effect of hyperglycemia

M.P Tarvainen, D.J. Cornforth, P Kuoppa, J.A. Lipponen, Herbert Jelinek

Research output: Book chapter/Published conference paperConference paperpeer-review

15 Citations (Scopus)

Abstract

Heart rate variability (HRV) is reduced in diabetes mellitus (DM) patients, suggesting dysfunction of cardiac autonomic regulation which has been associated with increased risk for pathological cardiac events. In this paper, we examined changes in HRV complexity in association to blood glucose level (BGL) and duration of diabetes. Resting HRV and BGL measurements of 32 healthy controls and 54 type 2 DM (T2DM) patients were analyzed. HRV complexity was assessed using Shannon entropy, sample entropy (SampEn), multiscale entropy (MSE), and multiscale Renyi entropy. HRV complexity increased with hyperglycemia indicated by increases in Shannon entropy and MSE and decreases in Renyi entropy for negative orders. Diabetes duration was strongly associated with Renyi entropy which increased for positive orders and decreased for negative orders as a function of disease duration. Shannon entropy, SampEn and MSE did not correlate with disease duration.
Original languageEnglish
Title of host publicationProceedings of the 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
Place of PublicationUnited States
PublisherIEEE, Institute of Electrical and Electronics Engineers
Pages5558-5561
Number of pages4
ISBN (Electronic)9781457702167
DOIs
Publication statusPublished - 2013
Event2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) - Osaka International Convention Center, Osaka, Japan
Duration: 03 Jul 201307 Jul 2013

Conference

Conference2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
Country/TerritoryJapan
CityOsaka
Period03/07/1307/07/13
OtherThe conference will cover diverse topics such as biomedical engineering, healthcare technologies, and medical and clinical applications. The conference program will consist of invited plenary lectures, symposia, workshops, invited sessions and oral and poster sessions of unsolicited contributions. All papers will be peer reviewed; accepted papers of up to four pages will appear in the Conference Proceedings and be indexed by IEEE Xplore and Medline/PubMed.

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