Complexity of heart rate variability in type 2 diabetes: Effect of hyperglycemia

M.P Tarvainen; D.J. Cornforth; P Kuoppa; J.A. Lipponen; Herbert Jelinek

doi:10.1109/EMBC.2013.6610809

Complexity of heart rate variability in type 2 diabetes: Effect of hyperglycemia

M.P Tarvainen, D.J. Cornforth, P Kuoppa, J.A. Lipponen, Herbert Jelinek

Research output: Book chapter/Published conference paper › Conference paper › peer-review

16 Citations (Scopus)

Abstract

Heart rate variability (HRV) is reduced in diabetes mellitus (DM) patients, suggesting dysfunction of cardiac autonomic regulation which has been associated with increased risk for pathological cardiac events. In this paper, we examined changes in HRV complexity in association to blood glucose level (BGL) and duration of diabetes. Resting HRV and BGL measurements of 32 healthy controls and 54 type 2 DM (T2DM) patients were analyzed. HRV complexity was assessed using Shannon entropy, sample entropy (SampEn), multiscale entropy (MSE), and multiscale Renyi entropy. HRV complexity increased with hyperglycemia indicated by increases in Shannon entropy and MSE and decreases in Renyi entropy for negative orders. Diabetes duration was strongly associated with Renyi entropy which increased for positive orders and decreased for negative orders as a function of disease duration. Shannon entropy, SampEn and MSE did not correlate with disease duration.

Original language	English
Title of host publication	Proceedings of the 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
Place of Publication	United States
Publisher	IEEE, Institute of Electrical and Electronics Engineers
Pages	5558-5561
Number of pages	4
ISBN (Electronic)	9781457702167
DOIs	https://doi.org/10.1109/EMBC.2013.6610809
Publication status	Published - 2013
Event	2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) - Osaka International Convention Center, Osaka, Japan Duration: 03 Jul 2013 → 07 Jul 2013

Conference

Conference	2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
Country/Territory	Japan
City	Osaka
Period	03/07/13 → 07/07/13
Other	The conference will cover diverse topics such as biomedical engineering, healthcare technologies, and medical and clinical applications. The conference program will consist of invited plenary lectures, symposia, workshops, invited sessions and oral and poster sessions of unsolicited contributions. All papers will be peer reviewed; accepted papers of up to four pages will appear in the Conference Proceedings and be indexed by IEEE Xplore and Medline/PubMed.

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10.1109/EMBC.2013.6610809

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Tarvainen, M. P., Cornforth, D. J., Kuoppa, P., Lipponen, J. A., & Jelinek, H. (2013). Complexity of heart rate variability in type 2 diabetes: Effect of hyperglycemia. In Proceedings of the 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) (pp. 5558-5561). IEEE, Institute of Electrical and Electronics Engineers. https://doi.org/10.1109/EMBC.2013.6610809

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title = "Complexity of heart rate variability in type 2 diabetes: Effect of hyperglycemia",

abstract = "Heart rate variability (HRV) is reduced in diabetes mellitus (DM) patients, suggesting dysfunction of cardiac autonomic regulation which has been associated with increased risk for pathological cardiac events. In this paper, we examined changes in HRV complexity in association to blood glucose level (BGL) and duration of diabetes. Resting HRV and BGL measurements of 32 healthy controls and 54 type 2 DM (T2DM) patients were analyzed. HRV complexity was assessed using Shannon entropy, sample entropy (SampEn), multiscale entropy (MSE), and multiscale Renyi entropy. HRV complexity increased with hyperglycemia indicated by increases in Shannon entropy and MSE and decreases in Renyi entropy for negative orders. Diabetes duration was strongly associated with Renyi entropy which increased for positive orders and decreased for negative orders as a function of disease duration. Shannon entropy, SampEn and MSE did not correlate with disease duration.",

keywords = "Autonomic regulation, Blood glucose level, Diabetes mellitus, Healthy controls, Heart rate variability, Measurements of, Multi-scale entropies, Shannon entropy",

author = "M.P Tarvainen and D.J. Cornforth and P Kuoppa and J.A. Lipponen and Herbert Jelinek",

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Tarvainen, MP, Cornforth, DJ, Kuoppa, P, Lipponen, JA & Jelinek, H 2013, Complexity of heart rate variability in type 2 diabetes: Effect of hyperglycemia. in Proceedings of the 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, Institute of Electrical and Electronics Engineers, United States, pp. 5558-5561, 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Osaka, Japan, 03/07/13. https://doi.org/10.1109/EMBC.2013.6610809

Complexity of heart rate variability in type 2 diabetes: Effect of hyperglycemia. / Tarvainen, M.P; Cornforth, D.J.; Kuoppa, P et al.
Proceedings of the 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). United States: IEEE, Institute of Electrical and Electronics Engineers, 2013. p. 5558-5561.

Research output: Book chapter/Published conference paper › Conference paper › peer-review

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AU - Kuoppa, P

AU - Lipponen, J.A.

AU - Jelinek, Herbert

N1 - Imported on 03 May 2017 - DigiTool details were: publisher = United States: IEEE, 2013. Event dates (773o) = 3-7 July, 2013; Parent title (773t) = IEEE Engineering in Medicine and Biology Society (EMBC).

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AB - Heart rate variability (HRV) is reduced in diabetes mellitus (DM) patients, suggesting dysfunction of cardiac autonomic regulation which has been associated with increased risk for pathological cardiac events. In this paper, we examined changes in HRV complexity in association to blood glucose level (BGL) and duration of diabetes. Resting HRV and BGL measurements of 32 healthy controls and 54 type 2 DM (T2DM) patients were analyzed. HRV complexity was assessed using Shannon entropy, sample entropy (SampEn), multiscale entropy (MSE), and multiscale Renyi entropy. HRV complexity increased with hyperglycemia indicated by increases in Shannon entropy and MSE and decreases in Renyi entropy for negative orders. Diabetes duration was strongly associated with Renyi entropy which increased for positive orders and decreased for negative orders as a function of disease duration. Shannon entropy, SampEn and MSE did not correlate with disease duration.

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Tarvainen MP, Cornforth DJ, Kuoppa P, Lipponen JA, Jelinek H. Complexity of heart rate variability in type 2 diabetes: Effect of hyperglycemia. In Proceedings of the 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). United States: IEEE, Institute of Electrical and Electronics Engineers. 2013. p. 5558-5561 doi: 10.1109/EMBC.2013.6610809

Complexity of heart rate variability in type 2 diabetes: Effect of hyperglycemia

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