Computational simulation of the early stage of bone healing under different configurations of locking compression plates

Saeed Miramini, Lihai Zhang, Martin Richardson, Marinis Pirpiris, Priyan Mendis, Kunle Oloyede, Glenn Edwards

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Flexible fixation or the so-called ‘biological fixation’ has been shown to encourage the formation of fracture callus, leading to better healing outcomes. However, the nature of the relationship between the degree of mechanical stability provided by a flexible fixation and the optimal healing outcomes has not been fully understood. In this study, we have developed a validated quantitative model to predict how cells in fracture callus might respond to change in their mechanical microenvironment due to different configurations of locking compression plate (LCP) in clinical practice, particularly in the early stage of healing. The model predicts that increasing flexibility of the LCP by changing the bone–plate distance (BPD) or the plate working length (WL) could enhance interfragmentary strain in the presence of a relatively large gap size (>3 mm). Furthermore, conventional LCP normally results in asymmetric tissue development during early stage of callus formation, and the increase of BPD or WL is insufficient to alleviate this problem.
Original languageEnglish
Pages (from-to)900-913
Number of pages14
JournalComputer Methods in Biomechanics and Biomedical Engineering
Volume18
Issue number8
Early online date2013
DOIs
Publication statusPublished - 2015

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