Consumption of anthocyanin-rich Queen Garnet plum juice reduces platelet activation related thrombogenesis in healthy volunteers

Abishek Santhakumar, Avinash Reddy Kundur, Kent Fanning, Michael Netzel, Roger Stanley, Indu Singh

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The anti-thrombotic properties of an anthocyanin-rich Queen Garnet plum juice (QGPJ) and anthocyanin-free prune juice (PJ) were studied in this randomised, double-blind, crossover trial. Twenty-one healthy subjects (M = 10, F = 11) consumed QGPJ, PJ or placebo, 200 mL/day for 28-days followed by a 2-week wash-out period. Only QGPJ supplementation inhibited platelet aggregation induced by ADP ( <5%, P = 0.02), collagen ( <2.7%, P <0.001) and arachidonic acid ( <4%, P <0.001); reduced platelet activation-dependent surface-marker P-selectin expression of activated de-granulated platelets ( <17.2%, P = 0.04); prolonged activated-partial thromboplastin clotting time (>2.1 s, P = 0.03); reduced plasma-fibrinogen ( <7.5%, P = 0.02) and malondialdehyde levels, a plasma biomarker of oxidative stress ( P = 0.016). PJ supplementation increased plasma hippuric acid content ( P = 0.018). QGPJ or PJ supplementation did not affect blood cell counts, lipid profile, or inflammation markers. Our findings suggest that QGPJ but not PJ has the potential to significantly attenuate thrombosis by reducing platelet activation/hyper-coagulability and oxidative stress.
Original languageEnglish
Pages (from-to)11-22
Number of pages12
JournalJournal of Functional Foods
Volume12
DOIs
Publication statusPublished - Jan 2015

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platelet activation
Anthocyanins
Platelet Activation
plums
volunteers
anthocyanins
juices
Healthy Volunteers
prunes
Oxidative Stress
Blood Cell Count
Malondialdehyde
Platelet Aggregation
Cross-Over Studies
Adenosine Diphosphate
Fibrinogen
Thrombosis
oxidative stress
Biomarkers
hippuric acid

Cite this

Santhakumar, Abishek ; Kundur, Avinash Reddy ; Fanning, Kent ; Netzel, Michael ; Stanley, Roger ; Singh, Indu. / Consumption of anthocyanin-rich Queen Garnet plum juice reduces platelet activation related thrombogenesis in healthy volunteers. In: Journal of Functional Foods. 2015 ; Vol. 12. pp. 11-22.
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abstract = "The anti-thrombotic properties of an anthocyanin-rich Queen Garnet plum juice (QGPJ) and anthocyanin-free prune juice (PJ) were studied in this randomised, double-blind, crossover trial. Twenty-one healthy subjects (M = 10, F = 11) consumed QGPJ, PJ or placebo, 200 mL/day for 28-days followed by a 2-week wash-out period. Only QGPJ supplementation inhibited platelet aggregation induced by ADP ( <5{\%}, P = 0.02), collagen ( <2.7{\%}, P <0.001) and arachidonic acid ( <4{\%}, P <0.001); reduced platelet activation-dependent surface-marker P-selectin expression of activated de-granulated platelets ( <17.2{\%}, P = 0.04); prolonged activated-partial thromboplastin clotting time (>2.1 s, P = 0.03); reduced plasma-fibrinogen ( <7.5{\%}, P = 0.02) and malondialdehyde levels, a plasma biomarker of oxidative stress ( P = 0.016). PJ supplementation increased plasma hippuric acid content ( P = 0.018). QGPJ or PJ supplementation did not affect blood cell counts, lipid profile, or inflammation markers. Our findings suggest that QGPJ but not PJ has the potential to significantly attenuate thrombosis by reducing platelet activation/hyper-coagulability and oxidative stress.",
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Consumption of anthocyanin-rich Queen Garnet plum juice reduces platelet activation related thrombogenesis in healthy volunteers. / Santhakumar, Abishek; Kundur, Avinash Reddy; Fanning, Kent; Netzel, Michael; Stanley, Roger; Singh, Indu.

In: Journal of Functional Foods, Vol. 12, 01.2015, p. 11-22.

Research output: Contribution to journalArticle

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AU - Santhakumar, Abishek

AU - Kundur, Avinash Reddy

AU - Fanning, Kent

AU - Netzel, Michael

AU - Stanley, Roger

AU - Singh, Indu

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AB - The anti-thrombotic properties of an anthocyanin-rich Queen Garnet plum juice (QGPJ) and anthocyanin-free prune juice (PJ) were studied in this randomised, double-blind, crossover trial. Twenty-one healthy subjects (M = 10, F = 11) consumed QGPJ, PJ or placebo, 200 mL/day for 28-days followed by a 2-week wash-out period. Only QGPJ supplementation inhibited platelet aggregation induced by ADP ( <5%, P = 0.02), collagen ( <2.7%, P <0.001) and arachidonic acid ( <4%, P <0.001); reduced platelet activation-dependent surface-marker P-selectin expression of activated de-granulated platelets ( <17.2%, P = 0.04); prolonged activated-partial thromboplastin clotting time (>2.1 s, P = 0.03); reduced plasma-fibrinogen ( <7.5%, P = 0.02) and malondialdehyde levels, a plasma biomarker of oxidative stress ( P = 0.016). PJ supplementation increased plasma hippuric acid content ( P = 0.018). QGPJ or PJ supplementation did not affect blood cell counts, lipid profile, or inflammation markers. Our findings suggest that QGPJ but not PJ has the potential to significantly attenuate thrombosis by reducing platelet activation/hyper-coagulability and oxidative stress.

KW - Anthocyanins

KW - Anti-platelet therapy

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