Copper(I) iodide-catalysed arylation of acetoacetate to yield 2-arylacetic acid esters

Jacob G. Zeevaart, Christopher J. Parkinson, Charles B. de Koning

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

The C-C coupling reaction between ethyl acetoacetate and aryl halides in the presence of CuI is described. The effects of solvent, ligands such as vicinal diamines and amino acids, base and temperature are reported. The arylated acetoacetate ester is deacylated under the reaction conditions resulting in the generation of 2-arylacetic acid esters, constituting a mild alternative to direct arylation of carboxylate esters.

Original languageEnglish
Pages (from-to)3289-3293
Number of pages5
JournalTetrahedron Letters
Volume48
Issue number18
DOIs
Publication statusPublished - 30 Apr 2007

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