Crystallographic structure determination and analysis of a potential short-chain dehydrogenase/reductase (SDR) from multidrug resistant Acinetobacter baumannii

Seyed Mohammad Ghafoori, Soha Abdollahpour, Paniz Shirmast, Jade K. Forwood

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Abstract

Bacterial antibiotic resistance remains an ever-increasing worldwide problem, requiring new approaches and enzyme targets. Acinetobacter baumannii is recognised as one of the most significant antibiotic-resistant bacteria, capable of carrying up to 45 different resistance genes, and new drug discovery targets for this organism is an urgent priority. Short-chain dehydrogenase/reductase enzymes are a large protein family with >60,000 members involved in numerous biosynthesis pathways. Here, we determined the structure of an SDR protein from A. baumannii and assessed the putative co-factor comparisons with previously co-crystalised enzymes and cofactors. This study provides a basis for future studies to examine these potential co-factors in vitro.

Original languageEnglish
Article numbere0289992
Pages (from-to)1-14
Number of pages14
JournalPLoS One
Volume18
Issue number8
DOIs
Publication statusPublished - Aug 2023

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