Decursin induces apoptosis in glioblastoma cells, but not in glial cells via a mitochondria-related caspase pathway

Seung Tack Oh, Seongmi Lee, Cai Hua, Byung Soo Koo, Sok Cheon Pak, Dong Il Kim, Songhee Jeon, Boo Ahn Shin

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Abstract

Decursin is a major biological active component of Angelica gigas Nakai and is known to induce apoptosis of metastatic prostatic cancer cells. Recently, other reports have been commissioned to examine the anticancer activities of this plant. In this study, we evaluated the inhibitory activity and related mechanism of action of decursin against glioblastoma cell line. Decursin demonstrated cytotoxic effects on U87 and C6 glioma cells in a dose-dependent manner but not in primary glial cells. Additionally, decursin increased apoptotic bodies and phosphorylated JNK and p38 in U87 cells. Decursin also down-regulated Bcl-2 as well as cell cycle dependent proteins, CDK-4 and cyclin D1. Furthermore, decursin-induced apoptosis was dependent on the caspase activation in U87 cells. Taken together, our data provide the evidence that decursin induces apoptosis in glioblastoma cells, making it a potential candidate as a chemotherapeutic drug against brain tumor.
Original languageEnglish
Pages (from-to)29-35
Number of pages7
JournalKorean Journal of Physiology and Pharmacology
Volume23
Issue number1
Early online date26 Dec 2018
DOIs
Publication statusPublished - Jan 2019

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