Detection of mild inherited disorders of blood coagulation: current options and personal recommendations

Giuseppe Lippi, Leonardo Pasalic, Emmanuel J Favaloro

Research output: Contribution to journalReview articlepeer-review

22 Citations (Scopus)

Abstract

Although assessment of prior personal and familial bleeding history is an important aspect of the diagnosis of bleeding disorders, patients with mild inherited bleeding disorders are sometimes clinically asymptomatic until presented with a hemostatic challenge. However, bleeding may occur after incursion of trauma or surgery, so detection of these conditions reflects an important facet of clinical and laboratory practice. Mild bleeding disorders may be detected as a result of family studies or following identification of abnormal values in first-line screening tests such as activated partial thromboplastin time, prothrombin time, fibrinogen and global platelet function screen testing, such as the platelet function analyzer. Following determination of abnormal screening tests, subsequent investigation should follow a systematic approach that targets specific diagnostic tests, and including factor assays, full platelet function assays and more extensive specialized hemostasis testing. The current report provides a personal overview on inherited disorders of blood coagulation and their detection.

Original languageEnglish
Pages (from-to)527-542
Number of pages16
JournalExpert Review of Hematology
Volume8
Issue number4
DOIs
Publication statusPublished - Aug 2015

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