Development of synthetic carbohydrate biomimetics as Urinary Tract Infection (UTI) prophylactics

Juan Mora, David Leaver

Research output: Other contribution to conferencePosterpeer-review

Abstract

Approx. 20 million women suffer from urinary tract infections (UTI) and the majority of UTI are caused by gram-neg. uropathogenic Escherichia coli (UPEC). There is a great need to develop prophylactics that can prevent UTI from occurring. UPEC utilizes the mannose-binding type I pilus adhesion protein FimH to colonize the bladder epithelium during UTI. The work described herein focuses on the development and synthesis of novel α-C-linked mannopyraoside triazoles as potential UTI prophylactics that have the ability to act as FimH antagonists. One of the key reactions utilized was the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction. The synthetic methodol. developed in this project can easily be modified to synthesize a large number of novel compounds that can be screened against UPEC.
Original languageEnglish
Publication statusPublished - 2018
Externally publishedYes
Event 74th Southwest Regional Meeting of the American Chemical Society - Little Rock, United States
Duration: 07 Nov 201810 Nov 2018

Conference

Conference 74th Southwest Regional Meeting of the American Chemical Society
Country/TerritoryUnited States
CityLittle Rock
Period07/11/1810/11/18

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