Development of synthetic carbohydrate biomimetics as Urinary Tract Infection (UTI) prophylactics

Juan Mora; David Leaver

Development of synthetic carbohydrate biomimetics as Urinary Tract Infection (UTI) prophylactics

Sul Ross State University

Research output: Other contribution to conference › Poster › peer-review

Abstract

Approx. 20 million women suffer from urinary tract infections (UTI) and the majority of UTI are caused by gram-neg. uropathogenic Escherichia coli (UPEC). There is a great need to develop prophylactics that can prevent UTI from occurring. UPEC utilizes the mannose-binding type I pilus adhesion protein FimH to colonize the bladder epithelium during UTI. The work described herein focuses on the development and synthesis of novel α-C-linked mannopyraoside triazoles as potential UTI prophylactics that have the ability to act as FimH antagonists. One of the key reactions utilized was the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction. The synthetic methodol. developed in this project can easily be modified to synthesize a large number of novel compounds that can be screened against UPEC.

Original language	English
Publication status	Published - 2018
Event	74th Southwest Regional Meeting of the American Chemical Society - Little Rock, United States Duration: 07 Nov 2018 → 10 Nov 2018 https://cen.acs.org/acs-news/meetings/2018-Southwest-Regional-Meeting/96/i38 (Meeting information)

Conference

Conference	74th Southwest Regional Meeting of the American Chemical Society
Abbreviated title	The natural state of chemistry
Country/Territory	United States
City	Little Rock
Period	07/11/18 → 10/11/18
Internet address	https://cen.acs.org/acs-news/meetings/2018-Southwest-Regional-Meeting/96/i38 (Meeting information)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Development of synthetic carbohydrate biomimetics as Urinary Tract Infection (UTI) prophylactics",

abstract = "Approx. 20 million women suffer from urinary tract infections (UTI) and the majority of UTI are caused by gram-neg. uropathogenic Escherichia coli (UPEC). There is a great need to develop prophylactics that can prevent UTI from occurring. UPEC utilizes the mannose-binding type I pilus adhesion protein FimH to colonize the bladder epithelium during UTI. The work described herein focuses on the development and synthesis of novel α-C-linked mannopyraoside triazoles as potential UTI prophylactics that have the ability to act as FimH antagonists. One of the key reactions utilized was the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction. The synthetic methodol. developed in this project can easily be modified to synthesize a large number of novel compounds that can be screened against UPEC.",

author = "Juan Mora and David Leaver",

year = "2018",

language = "English",

note = " 74th Southwest Regional Meeting of the American Chemical Society, The natural state of chemistry ; Conference date: 07-11-2018 Through 10-11-2018",

url = "https://cen.acs.org/acs-news/meetings/2018-Southwest-Regional-Meeting/96/i38",

}

TY - CONF

T1 - Development of synthetic carbohydrate biomimetics as Urinary Tract Infection (UTI) prophylactics

AU - Mora, Juan

AU - Leaver, David

PY - 2018

Y1 - 2018

N2 - Approx. 20 million women suffer from urinary tract infections (UTI) and the majority of UTI are caused by gram-neg. uropathogenic Escherichia coli (UPEC). There is a great need to develop prophylactics that can prevent UTI from occurring. UPEC utilizes the mannose-binding type I pilus adhesion protein FimH to colonize the bladder epithelium during UTI. The work described herein focuses on the development and synthesis of novel α-C-linked mannopyraoside triazoles as potential UTI prophylactics that have the ability to act as FimH antagonists. One of the key reactions utilized was the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction. The synthetic methodol. developed in this project can easily be modified to synthesize a large number of novel compounds that can be screened against UPEC.

AB - Approx. 20 million women suffer from urinary tract infections (UTI) and the majority of UTI are caused by gram-neg. uropathogenic Escherichia coli (UPEC). There is a great need to develop prophylactics that can prevent UTI from occurring. UPEC utilizes the mannose-binding type I pilus adhesion protein FimH to colonize the bladder epithelium during UTI. The work described herein focuses on the development and synthesis of novel α-C-linked mannopyraoside triazoles as potential UTI prophylactics that have the ability to act as FimH antagonists. One of the key reactions utilized was the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction. The synthetic methodol. developed in this project can easily be modified to synthesize a large number of novel compounds that can be screened against UPEC.

UR - https://www.sulross.edu/sul-ross-chemists-attend-the-74th-american-chemical-society-southwest-regional-meeting/

M3 - Poster

T2 - 74th Southwest Regional Meeting of the American Chemical Society

Y2 - 7 November 2018 through 10 November 2018

ER -

Development of synthetic carbohydrate biomimetics as Urinary Tract Infection (UTI) prophylactics

Abstract

Conference

UN SDGs

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