Approx. 20 million women suffer from urinary tract infections (UTI) and the majority of UTI are caused by gram-neg. uropathogenic Escherichia coli (UPEC). There is a great need to develop prophylactics that can prevent UTI from occurring. UPEC utilizes the mannose-binding type I pilus adhesion protein FimH to colonize the bladder epithelium during UTI. The work described herein focuses on the development and synthesis of novel α-C-linked mannopyraoside triazoles as potential UTI prophylactics that have the ability to act as FimH antagonists. One of the key reactions utilized was the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction. The synthetic methodol. developed in this project can easily be modified to synthesize a large number of novel compounds that can be screened against UPEC.
|Publication status||Published - 2018|
|Event|| 74th Southwest Regional Meeting of the American Chemical Society - Little Rock, United States|
Duration: 07 Nov 2018 → 10 Nov 2018
|Conference||74th Southwest Regional Meeting of the American Chemical Society|
|Period||07/11/18 → 10/11/18|